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    Pcolce2 procollagen C-endopeptidase enhancer 2 [ Mus musculus (house mouse) ]

    Gene ID: 76477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcolce2provided by MGI
    Official Full Name
    procollagen C-endopeptidase enhancer 2provided by MGI
    Primary source
    MGI:MGI:1923727
    See related
    Ensembl:ENSMUSG00000015354 AllianceGenome:MGI:1923727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcpe2; 2400001O18Rik
    Summary
    Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; jaw; limb; nasal cavity epithelium; and skeleton. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 28.4), liver E18 (RPKM 4.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcolce2 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95519681..95577604)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95637628..95695551)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32542 Neighboring gene STARR-seq mESC enhancer starr_24936 Neighboring gene predicted gene 16126 Neighboring gene predicted gene, 25582 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 2 Neighboring gene predicted gene, 39407 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene plastin 1 (I-isoform) Neighboring gene VISTA enhancer mm1367

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload. Baicu CF, et al. Am J Physiol Heart Circ Physiol, 2012 Jul 15. PMID 22610170, Free PMC Article
    2. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases. Vadon-Le Goff S, et al. Nat Commun, 2023 Dec 4. PMID 38049428, Free PMC Article
    3. Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake. Pollard RD, et al. J Biol Chem, 2015 Jun 19. PMID 25947382, Free PMC Article
    4. Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. Francone OL, et al. J Lipid Res, 2011 Nov. PMID 21771977, Free PMC Article
    5. The aryl hydrocarbon receptor is required for normal gonadotropin responsiveness in the mouse ovary. Barnett KR, et al. Toxicol Appl Pharmacol, 2007 Aug 15. PMID 17594909, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
      Title: Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.
    2. PCPE2 was shown to enhance SR-BI function by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing SR-BI localization and/or conformation.
      Title: Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.
    3. It was shown that PCOLCE2 is required for efficient procollagen processing and deposition of fibrillar collagen in the pressure-overloaded myocardium.
      Title: Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload.
    4. the role of the PCPE2 protein in an in vivo model
      Title: Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
    5. Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9.
      Title: Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23.
    6. PCPE2 is shown to be a glycoprotein that differs markedly in the nature of its glycosylation from that of PCPE1
      Title: PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    procollagen C-endopeptidase enhancer 2
    Names
    PCPE-2
    procollagen C-proteinase enhancer 2
    procollagen COOH-terminal proteinase enhancer 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029620.2 → NP_083896.1  procollagen C-endopeptidase enhancer 2 precursor

      See identical proteins and their annotated locations for NP_083896.1

      Status: VALIDATED

      Source sequence(s)
      AK010249, AK132395
      Consensus CDS
      CCDS23410.1
      UniProtKB/Swiss-Prot
      Q3V1K6, Q8R4W6, Q9CX06
      Related
      ENSMUSP00000015498.9, ENSMUST00000015498.9
      Conserved Domains (3) summary
      cd00041
      Location:32 → 142
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd03576
      Location:291 → 414
      NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...
      pfam00431
      Location:153 → 264
      CUB; CUB domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      95519681..95577604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4W6.2 GenPept UniProtKB/Swiss-Prot:Q8R4W6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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