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    Polr3b polymerase (RNA) III (DNA directed) polypeptide B [ Mus musculus (house mouse) ]

    Gene ID: 70428, updated on 10-Dec-2024

    Summary

    Official Symbol
    Polr3bprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Bprovided by MGI
    Primary source
    MGI:MGI:1917678
    See related
    Ensembl:ENSMUSG00000034453 AllianceGenome:MGI:1917678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C128; RPC2; 2700078H01Rik; A330032P03Rik
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity; DNA/RNA hybrid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and snRNA transcription by RNA polymerase III. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Polr3b in Genome Data Viewer
    Location:
    10 C1; 10 41.58 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84458156..84563042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84622292..84727178)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6893 Neighboring gene t-complex 11 (mouse) like 2 Neighboring gene STARR-positive B cell enhancer ABC_E3905 Neighboring gene predicted gene, 25657 Neighboring gene STARR-seq mESC enhancer starr_27418 Neighboring gene predicted gene, 17249 Neighboring gene STARR-seq mESC enhancer starr_27420 Neighboring gene STARR-seq mESC enhancer starr_27422 Neighboring gene STARR-seq mESC enhancer starr_27426 Neighboring gene STARR-seq mESC enhancer starr_27427 Neighboring gene STARR-positive B cell enhancer ABC_E8354 Neighboring gene regulatory factor X, 4 (influences HLA class II expression) Neighboring gene STARR-positive B cell enhancer ABC_E6894 Neighboring gene predicted gene, 53596 Neighboring gene predicted gene, 40728 Neighboring gene STARR-seq mESC enhancer starr_27430

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA/RNA hybrid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA/RNA hybrid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase IV activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase V activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitochondrial single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plastid single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plastid transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in snRNA transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase IV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase V IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC2
    Names
    DNA-directed RNA polymerase III 127.6 kDa polypeptide
    DNA-directed RNA polymerase III subunit B
    RNA polymerase III subunit C2
    RNA polymerase III subunit RPC2 homolog
    NP_081699.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027423.2NP_081699.1  DNA-directed RNA polymerase III subunit RPC2

      See identical proteins and their annotated locations for NP_081699.1

      Status: VALIDATED

      Source sequence(s)
      AK165886, BC068143
      Consensus CDS
      CCDS24081.1
      UniProtKB/Swiss-Prot
      P59470, Q6NVF3
      Related
      ENSMUSP00000076418.6, ENSMUST00000077175.7
      Conserved Domains (3) summary
      cd00653
      Location:391127
      RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
      pfam04566
      Location:539600
      RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
      pfam04567
      Location:621661
      RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      84458156..84563042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_380439.5 RNA Sequence