Faah fatty acid amide hydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Faahprovided by MGI
Official Full Name: fatty acid amide hydrolaseprovided by MGI
Primary source: MGI:MGI:109609
See related: Ensembl:ENSMUSG00000034171 AllianceGenome:MGI:109609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables monoacylglycerol lipase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 30.1), duodenum adult (RPKM 29.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.08 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115853866..115876034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115996668..116018837, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats.
Title: Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats.
Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition.
Title: Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition.
FAAH inhibition ameliorates breast cancer in a murine model.
Title: FAAH inhibition ameliorates breast cancer in a murine model.
Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice.
Title: Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice.
Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates Cisplatin-Induced Nephropathy in Mice.
Title: Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates Cisplatin-Induced Nephropathy in Mice.
Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury.
Title: Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury.
Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice.
Title: Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice.
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH.
Title: Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH.
These data demonstrate that FAAH activity is required for leptin's hypophagic effects
Title: Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance.
The purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in Operant sensation seeking utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice.
Title: Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

U82536 (e-PCR)
- UniSTS:159274

AW412498 (e-PCR)
- UniSTS:179050

Faah (e-PCR), detects polymorphism
- UniSTS:143059

Faah (e-PCR), detects polymorphism
- UniSTS:143060

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidase activity	IEA Inferred from Electronic Annotation more info
enables amidase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid amide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid amide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid amide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, acting on ester bonds	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty-acid amide hydrolase 1

Names: amide hydrolase; anandamide amidohydrolase 1; fatty acid amide hydrolase protein; fatty acid ester hydrolase; oleamide hydrolase 1

NP_034303.3

EC 3.5.1.99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010173.6 → NP_034303.3 fatty-acid amide hydrolase 1

Status: VALIDATED

Source sequence(s)

AL627105

Consensus CDS

CCDS18501.1

UniProtKB/Swiss-Prot

O08914, Q922S0, Q9DBF5

UniProtKB/TrEMBL

Q8C541

Related

ENSMUSP00000041543.5, ENSMUST00000049095.6

Conserved Domains (1) summary

pfam01425
Location:95 → 562

Amidase; Amidase