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    DSCAM-AS1 DSCAM antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506492, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DSCAM-AS1provided by HGNC
    Official Full Name
    DSCAM antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:40197
    See related
    Ensembl:ENSG00000235123 AllianceGenome:HGNC:40197
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M41
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See DSCAM-AS1 in Genome Data Viewer
    Location:
    21q22.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (40383083..40385358)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (38771917..38774192)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (41755010..41757285)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:41241262-41241415 Neighboring gene meiotic recombination hotspot PCP4-1 Neighboring gene meiotic recombination hotspot PCP4-2 Neighboring gene Purkinje cell protein 4 Neighboring gene MPRA-validated peak4411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:41400415-41400914 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:41436401-41436568 Neighboring gene NANOG hESC enhancer GRCh37_chr21:41474546-41475047 Neighboring gene DS cell adhesion molecule Neighboring gene microRNA 4760 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:41709903-41711102 Neighboring gene uncharacterized LOC105369294 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:41792223-41793422 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer. Hu C. Mini Rev Med Chem, 2023. PMID 35996247
    2. Identification of mRNAs differentially-expressed between benign and malignant breast tumour cells. Liu D, et al. Br J Cancer, 2002 Aug 12. PMID 12177779, Free PMC Article
    3. Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer. Miano V, et al. Oncotarget, 2016 Jan 19. PMID 26621851, Free PMC Article
    4. The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Niknafs YS, et al. Nat Commun, 2016 Sep 26. PMID 27666543, Free PMC Article
    5. DSCAM-AS1 regulates the G(1) /S cell cycle transition and is an independent prognostic factor of poor survival in luminal breast cancer patients treated with endocrine therapy. Sun W, et al. Cancer Med, 2018 Dec. PMID 30430768, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis.
      Title: METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis.
    2. LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer.
      Title: LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer.
    3. DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p.
      Title: DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p.
    4. LncRNA DSCAM-AS1 Negatively Interacts with miR-124 to Promote Hepatocellular Carcinoma Proliferation.
      Title: LncRNA DSCAM-AS1 Negatively Interacts with miR-124 to Promote Hepatocellular Carcinoma Proliferation.
    5. Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis.
      Title: Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis.
    6. Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma.
      Title: Upregulation of the long noncoding RNAs DSCAM-AS1 and MANCR is a potential diagnostic marker for breast carcinoma.
    7. Long non-coding RNA (lncRNA) DSCAM-AS1 is upregulated in breast cancer.
      Title: Long non-coding RNA (lncRNA) DSCAM-AS1 is upregulated in breast cancer.
    8. DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling.
      Title: DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling.
    9. LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network.
      Title: LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network.
    10. The clinical significance of circulating DSCAM-AS1 in patients with ER-positive breast cancer and construction of its competitive endogenous RNA network.
      Title: The clinical significance of circulating DSCAM-AS1 in patients with ER-positive breast cancer and construction of its competitive endogenous RNA network.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • DSCAM antisense RNA 1 (non-protein coding)

    Clone Names

    • AF042090.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038896.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF401029, AF401033
      Related
      ENST00000427451.6

    2. NR_038898.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a distinct and shorter internal segment, compared to variant 1.
      Source sequence(s)
      AF401029
      Related
      ENST00000455354.2

    3. NR_038899.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a distinct and shorter internal segment, compared to variant 1.
      Source sequence(s)
      AF401029, AF401035
      Related
      ENST00000422749.6

    4. NR_038900.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AF401030
      Related
      ENST00000444046.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      40383083..40385358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791814.1 Reference GRCh38.p14 PATCHES

      Range
      522737..525012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      38771917..38774192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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