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    ZBTB20 zinc finger and BTB domain containing 20 [ Homo sapiens (human) ]

    Gene ID: 26137, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZBTB20provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 20provided by HGNC
    Primary source
    HGNC:HGNC:13503
    See related
    Ensembl:ENSG00000181722 MIM:606025; AllianceGenome:HGNC:13503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOF; DPZF; PRIMS; ODA-8S; ZNF288
    Summary
    This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
    Expression
    Ubiquitous expression in kidney (RPKM 4.0), ovary (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB20 in Genome Data Viewer
    Location:
    3q13.31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (114314500..115147288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (117035293..117867765, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (114033347..114866135, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114017997-114018498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114018499-114018998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20274 Neighboring gene uncharacterized LOC124909411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:114074859-114075500 Neighboring gene ZBTB20 antisense RNA 1 Neighboring gene T cell immunoreceptor with Ig and ITIM domains Neighboring gene microRNA 568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20277 Neighboring gene ZBTB20 antisense RNA 5 Neighboring gene VISTA enhancer hs253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20278 Neighboring gene microRNA 4796 Neighboring gene ZBTB20 antisense RNA 3 Neighboring gene Y-box binding protein 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20279 Neighboring gene ZBTB20 antisense RNA 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20284 Neighboring gene VISTA enhancer hs1648 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:114958135-114959334 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:115003756-115004955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115036984-115037582 Neighboring gene eukaryotic translation initiation factor 4E family member 2 pseudogene 2 Neighboring gene uncharacterized LOC105374051

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Assessment of the association between ZBTB20 rs9841504 polymorphism and gastric and esophageal cancer susceptibility: a meta-analysis. Shi J, et al. Int J Biol Markers, 2017 Mar 2. PMID 27646774
    2. HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma. He Z, et al. Mol Med Rep, 2020 Jul. PMID 32319639, Free PMC Article
    3. Primrose syndrome: Characterization of the phenotype in 42 patients. Melis D, et al. Clin Genet, 2020 Jun. PMID 32266967, Free PMC Article
    4. Primrose syndrome: a phenotypic comparison of patients with a ZBTB20 missense variant versus a 3q13.31 microdeletion including ZBTB20. Juven A, et al. Eur J Hum Genet, 2020 Aug. PMID 32071410, Free PMC Article
    5. Primrose syndrome associated with unclassified immunodeficiency and a novel ZBTB20 mutation. Yamamoto-Shimojima K, et al. Am J Med Genet A, 2020 Mar. PMID 31821719

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Le miR-224-5p regule sert de biomarqueur pour l'insuffisance hepatique aigue pediatrique et regule l'inflammation en modulant ZBTB20].
      Title: [Le miR-224-5p régulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20].
    2. Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.
      Title: Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.
    3. Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.
      Title: Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.
    4. Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis.
      Title: Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis.
    5. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
      Title: The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
    6. Spatial control of astrogenesis progression by cortical arealization genes.
      Title: Spatial control of astrogenesis progression by cortical arealization genes.
    7. Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
      Title: Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
    8. An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.
      Title: An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.
    9. LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.
      Title: LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.
    10. Primrose syndrome: Characterization of the phenotype in 42 patients.
      Title: Primrose syndrome: Characterization of the phenotype in 42 patients.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Primrose syndrome
    MedGen: C0796121 OMIM: 259050 GeneReviews: Primrose Syndrome
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
    EBI GWAS Catalog
    A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13240, FLJ26458, DKFZp566F123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 20
    Names
    BTB/POZ zinc finger protein DPZF
    dendritic cell-derived BTB/POZ zinc finger
    zinc finger protein 288

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052992.1 RefSeqGene

      Range
      4993..837781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164342.2 → NP_001157814.1  zinc finger and BTB domain-containing protein 20 isoform 1

      See identical proteins and their annotated locations for NP_001157814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC093010, AC131152, AF139460, BC090936, BG993862
      Consensus CDS
      CCDS54626.1
      UniProtKB/Swiss-Prot
      Q63HP6, Q8N6R5, Q9HC78, Q9Y410
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:352 → 442
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:378 → 571
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. NM_001164343.2 → NP_001157815.1  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001157815.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC093010, AC131152, BC090936, BF327758
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000420324.1, ENST00000462705.5
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. NM_001164344.4 → NP_001157816.1  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001157816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC093010, AC131152, AL050276, DB131355
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000417307.1, ENST00000464560.5
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    4. NM_001164345.4 → NP_001157817.1  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001157817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC093010, AC131152, AK225788, BC090936
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000419902.1, ENST00000471418.5
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. NM_001164346.2 → NP_001157818.1  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001157818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC093010, AC131152, AK315307, BC090936, DB268190
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000420684.2, ENST00000470311.6
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    6. NM_001164347.2 → NP_001157819.1  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001157819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC093010, AC131152, BC029041, BC090936
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000418092.1, ENST00000481632.5
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    7. NM_001348800.3 → NP_001335729.1  zinc finger and BTB domain-containing protein 20 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1 and, like variant 1, encodes isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS54626.1
      UniProtKB/Swiss-Prot
      Q63HP6, Q8N6R5, Q9HC78, Q9Y410
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000501561.1, ENST00000675478.1
      Conserved Domains (7) summary
      PHA03169
      Location:352 → 442
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:378 → 571
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    8. NM_001348801.3 → NP_001335730.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    9. NM_001348802.3 → NP_001335731.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    10. NM_001348803.3 → NP_001335732.1  zinc finger and BTB domain-containing protein 20 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1 and, like variant 1, encodes isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS54626.1
      UniProtKB/Swiss-Prot
      Q63HP6, Q8N6R5, Q9HC78, Q9Y410
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000419153.1, ENST00000474710.6
      Conserved Domains (7) summary
      PHA03169
      Location:352 → 442
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:378 → 571
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    11. NM_001348804.3 → NP_001335733.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    12. NM_001348805.3 → NP_001335734.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    13. NM_001393393.1 → NP_001380322.1  zinc finger and BTB domain-containing protein 20 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC055739, AC078986, AC083886, AC093010, AC131152
      Consensus CDS
      CCDS54626.1
      UniProtKB/Swiss-Prot
      Q63HP6, Q8N6R5, Q9HC78, Q9Y410
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000502480.1, ENST00000676079.1
      Conserved Domains (7) summary
      PHA03169
      Location:352 → 442
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:378 → 571
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    14. NM_001393394.1 → NP_001380323.1  zinc finger and BTB domain-containing protein 20 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC055739, AC078986, AC083886, AC093010, AC131152
      Consensus CDS
      CCDS54626.1
      UniProtKB/Swiss-Prot
      Q63HP6, Q8N6R5, Q9HC78, Q9Y410
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:352 → 442
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam09606
      Location:378 → 571
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    15. NM_001393395.1 → NP_001380324.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC055739, AC078986, AC083886, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    16. NM_001393396.1 → NP_001380325.1  zinc finger and BTB domain-containing protein 20 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC055739, AC078986, AC083886, AC093010, AC131152
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    17. NM_015642.7 → NP_056457.3  zinc finger and BTB domain-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_056457.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC069063, AC093010, AC131152, BC090936, BX647778
      Consensus CDS
      CCDS2981.1
      UniProtKB/TrEMBL
      A8K251, B2RCW4
      Related
      ENSP00000349803.3, ENST00000357258.8
      Conserved Domains (7) summary
      PHA03169
      Location:279 → 369
      PHA03169; hypothetical protein; Provisional
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RNA

    1. NR_121662.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three exons and contains mutliple alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AC069506, AC093010, AC131152, CB164748, DA120543

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      114314500..115147288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      117035293..117867765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HC78.3 GenPept UniProtKB/Swiss-Prot:Q9HC78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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