ACB1 long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ACB1
Official Full Name: long-chain fatty acid transporter ACB1
Primary source: SGD:S000003269
Locus tag: YGR037C
See related: AllianceGenome:SGD:S000003269; FungiDB:YGR037C; VEuPathDB:YGR037C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables long-chain fatty acyl-CoA binding activity. Involved in very long-chain fatty acid biosynthetic process. Located in extracellular region. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to several human genes including DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ACB1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (559731..559994, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
Title: Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
The major ESCRT-III subunit Snf7 localizes transiently to vesicles and tubules surrounded by a cup-shaped membrane and this was accelerated in vps4Delta cells, correlating with increased Acb1 secretion.
Title: ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.
These experiments reveal a unique secretory pathway where autophagosomes containing Acb1 evade fusion with the vacuole to prevent cargo degradation.
Title: Unconventional secretion of Acb1 is mediated by autophagosomes.
study of the cardiolipin species profile in Saccharomyces cerevisiae by using depletion of the acyl-CoA-binding protein Acb1p
Title: Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.
phospholipid biosynthesis gene expression is modulated either by the Acb1p-acyl-CoA ester complex directly or by its ability to donate acyl-CoA esters to utilizing systems.
Title: Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transporter ACB1

NP_011551.3

Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

559731..559994 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181166.3 → NP_011551.3 TPA: long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011551.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUH4, P31787, Q45U46

UniProtKB/TrEMBL

A6ZV26, B3LII3, C7GKA4, C8Z8T3, G2WEC8, N1P3G4

Conserved Domains (1) summary

COG4281
Location:1 → 87

ACB; Acyl-CoA-binding protein [Lipid transport and metabolism]