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    SYTL4 synaptotagmin like 4 [ Homo sapiens (human) ]

    Gene ID: 94121, updated on 10-Dec-2024

    Summary

    Official Symbol
    SYTL4provided by HGNC
    Official Full Name
    synaptotagmin like 4provided by HGNC
    Primary source
    HGNC:HGNC:15588
    See related
    Ensembl:ENSG00000102362 MIM:300723; AllianceGenome:HGNC:15588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLP4
    Summary
    This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
    Expression
    Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SYTL4 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (100674491..100732121, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99116950..99174573, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (99929488..99987108, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20914 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:99890767-99891382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:99891383-99891998 Neighboring gene tetraspanin 6 Neighboring gene Sharpr-MPRA regulatory region 6756 Neighboring gene Sharpr-MPRA regulatory region 14263 Neighboring gene sushi repeat containing protein X-linked 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20916 Neighboring gene Sharpr-MPRA regulatory region 15282 Neighboring gene peptidylprolyl isomerase A pseudogene 89 Neighboring gene RAD21 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40960, DKFZp451P0116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neurexin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-like protein 4
    Names
    exophilin-2
    granuphilin-a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016858.2 RefSeqGene

      Range
      5026..62656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129896.3NP_001123368.1  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001123368.1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    2. NM_001174068.2NP_001167539.1  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001167539.1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000276141.6, ENST00000276141.10
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    3. NM_001370160.1NP_001357089.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    4. NM_001370161.1NP_001357090.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000263033.5, ENST00000263033.9
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    5. NM_001370162.1NP_001357091.1  synaptotagmin-like protein 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL390040
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8121
      FYVE_2; FYVE-type zinc finger
    6. NM_001370163.1NP_001357092.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    7. NM_001370164.1NP_001357093.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    8. NM_001370165.1NP_001357094.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000362080.1, ENST00000372989.6
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    9. NM_001370166.1NP_001357095.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    10. NM_001370167.1NP_001357096.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000509693.1, ENST00000685623.1
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    11. NM_001370168.1NP_001357097.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    12. NM_001370169.1NP_001357098.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily
    13. NM_080737.3NP_542775.2  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_542775.2

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8121
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      100674491..100732121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029968.2XP_016885457.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8121
      FYVE_2; FYVE-type zinc finger
    2. XM_017029967.3XP_016885456.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8121
      FYVE_2; FYVE-type zinc finger
    3. XM_047442649.1XP_047298605.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    4. XM_017029966.2XP_016885455.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8121
      FYVE_2; FYVE-type zinc finger
    5. XM_047442651.1XP_047298607.1  synaptotagmin-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
    6. XM_047442650.1XP_047298606.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99116950..99174573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328140.1XP_054184115.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    2. XM_054328137.1XP_054184112.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    3. XM_054328139.1XP_054184114.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    4. XM_054328138.1XP_054184113.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    5. XM_054328142.1XP_054184117.1  synaptotagmin-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A8K973, B2R7R4
    6. XM_054328141.1XP_054184116.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4