Ifngr1 interferon gamma receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifngr1provided by MGI
Official Full Name: interferon gamma receptor 1provided by MGI
Primary source: MGI:MGI:107655
See related: Ensembl:ENSMUSG00000020009 AllianceGenome:MGI:107655
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
Summary: Predicted to enable type II interferon receptor activity. Involved in glial cell activation; negative regulation of amyloid-beta clearance; and positive regulation of macromolecule metabolic process. Acts upstream of or within defense response to virus. Predicted to be located in dendrite and vesicle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; bone; cerebral cortex; female reproductive system; and liver. Used to study osteoporosis. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 45.9), colon adult (RPKM 37.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 8.49 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (19467697..19485977)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (19591949..19610229)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of the IFN-gamma signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions.
Title: Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions.
Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model.
Title: Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model.
Downregulation of Interferon-gamma Receptor Expression Endows Resistance to Anti-Programmed Death Protein 1 Therapy in Colorectal Cancer.
Title: Downregulation of Interferon-γ Receptor Expression Endows Resistance to Anti-Programmed Death Protein 1 Therapy in Colorectal Cancer.
Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition.
Title: Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition.
Rotavirus Reprograms Multiple Interferon Receptors and Restricts Their Intestinal Antiviral and Inflammatory Functions.
Title: Rotavirus Reprograms Multiple Interferon Receptors and Restricts Their Intestinal Antiviral and Inflammatory Functions.
Data data demonstrate that there are multiple mechanisms by which IFNGR1 availability is regulated in myeloid cells, which is counter to the accepted dogma that IFNGR is constitutively expressed.
Title: Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness.
Interferon-gamma Receptor 1 and GluR1 upregulated in motor neurons of symptomatic hSOD 1G93A mice, a model of Amyotrophic Lateral Sclerosis.
Title: Interferon-γ Receptor 1 and GluR1 upregulated in motor neurons of symptomatic hSOD1G93A mice.
Canonical Ifn-gamma signaling via Ifngr1 and Stat1 is required for Parkinsonian neurodegenerative pathology
Title: Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.
An Hematopoietic Stem Cell-based gene therapy approach for IFNgammaR1 deficiency, which protects mice from severe mycobacterial infections, thereby laying the foundation for a new therapeutic intervention in corresponding human patients.
Title: Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.
significant upregulation of genes involved in inflammation and tissue remodeling in intestinal tumors of Ifngr1-/-ApcMin/+ mice when compared to those in Ifngr1+/+ApcMin/+ mice
Title: Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (11) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M26711 (e-PCR)
- UniSTS:159956

PMC96762P1 (e-PCR)
- UniSTS:273632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type II interferon receptor activity	IEA Inferred from Electronic Annotation more info
enables type II interferon receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of amyloid-beta formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type III interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type III interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon gamma receptor 1

Names: IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; INF-g receptor; interferon gamma receptor alpha-chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.