SPRY1 sprouty RTK signaling antagonist 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPRY1provided by HGNC
Official Full Name: sprouty RTK signaling antagonist 1provided by HGNC
Primary source: HGNC:HGNC:11269
See related: Ensembl:ENSG00000164056 MIM:602465; AllianceGenome:HGNC:11269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hSPRY1
Summary: Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q28.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (123396795..123403760)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (126700894..126707854)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (124317950..124324915)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms.
Title: Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms.
Increased SPRY1 expression activates NF-kappaB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
Title: Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
Title: Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.
Title: Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.
Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
Title: Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
SPRY1 promotes cell proliferation and inhibits apoptosis by activating Hedgehog pathway in acute myeloid leukemia.
Title: SPRY1 promotes cell proliferation and inhibits apoptosis by activating Hedgehog pathway in acute myeloid leukemia.
Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
Title: Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.
Title: A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.
Circ_0020093 ameliorates IL-1beta-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.
Title: Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.
Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
Title: Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif upregulates the expression of sprouty homolog 1 protein (SPRY1, antagonist of FGF signaling) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH98770 (e-PCR)
- UniSTS:88602

RH66329 (e-PCR)
- UniSTS:67516

SHGC-59592 (e-PCR)
- UniSTS:58879

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bud elongation involved in lung branching	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in metanephros development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in organ induction	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein sprouty homolog 1

Names: sprouty homolog 1, antagonist of FGF signaling; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); spry-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258038.2 → NP_001244967.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_001244967.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest variant. Variants 1-4 encode the same protein.

Source sequence(s)

AL602431, AY590694, CA447611, DA765300

Consensus CDS

CCDS3731.1

UniProtKB/Swiss-Prot

D3DNX6, O43609, Q6PNE0

Related

ENSP00000498292.1, ENST00000651917.1

Conserved Domains (1) summary

pfam05210
Location:187 → 284

Sprouty; Sprouty protein (Spry)
NM_001258039.1 → NP_001244968.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_001244968.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

AV692593, AY590694, CA447611, CN302060

Consensus CDS

CCDS3731.1

UniProtKB/Swiss-Prot

D3DNX6, O43609, Q6PNE0

Related

ENSP00000480540.1, ENST00000622283.1

Conserved Domains (1) summary

pfam05210
Location:187 → 284

Sprouty; Sprouty protein (Spry)
NM_001375410.1 → NP_001362339.1 protein sprouty homolog 1

Status: VALIDATED

Source sequence(s)

AC026402

Consensus CDS

CCDS3731.1

UniProtKB/Swiss-Prot

D3DNX6, O43609, Q6PNE0

Conserved Domains (1) summary

pfam05210
Location:187 → 284

Sprouty; Sprouty protein (Spry)
NM_005841.3 → NP_005832.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_005832.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC063856, CA447611

Consensus CDS

CCDS3731.1

UniProtKB/Swiss-Prot

D3DNX6, O43609, Q6PNE0

Related

ENSP00000377871.2, ENST00000394339.2

Conserved Domains (1) summary

pfam05210
Location:187 → 284

Sprouty; Sprouty protein (Spry)
NM_199327.3 → NP_955359.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_955359.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5'UTR, compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

AL602431, AY192146, AY590694, CA447611

Consensus CDS

CCDS3731.1

UniProtKB/Swiss-Prot

D3DNX6, O43609, Q6PNE0

Related

ENSP00000343785.1, ENST00000339241.1

Conserved Domains (1) summary

pfam05210
Location:187 → 284

Sprouty; Sprouty protein (Spry)