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    Mir100hg Mir100 Mirlet7a-2 Mir125b-1 cluster host gene [ Mus musculus (house mouse) ]

    Gene ID: 73144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mir100hgprovided by MGI
    Official Full Name
    Mir100 Mirlet7a-2 Mir125b-1 cluster host geneprovided by MGI
    Primary source
    MGI:MGI:1920394
    See related
    Ensembl:ENSMUSG00000074415 AllianceGenome:MGI:1920394
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Mgi9; 2610203C20Rik; 3110039I08Rik; D230004N17Rik
    Summary
    Is expressed in telencephalon. Orthologous to human MIR100HG (mir-100-let-7a-2-mir-125b-1 cluster host gene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 48.2), whole brain E14.5 (RPKM 42.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mir100hg in Genome Data Viewer
    Location:
    9 A5.1; 9 23.32 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (41287822..41526481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (41376526..41615185)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700063D05 gene Neighboring gene STARR-seq mESC enhancer starr_23877 Neighboring gene STARR-seq mESC enhancer starr_23879 Neighboring gene STARR-seq mESC enhancer starr_23880 Neighboring gene VISTA enhancer mm1486 Neighboring gene predicted gene, 25401 Neighboring gene STARR-seq mESC enhancer starr_23882 Neighboring gene microRNA let7a-2 Neighboring gene microRNA 100 Neighboring gene predicted gene, 51670 Neighboring gene predicted gene, 51735 Neighboring gene microRNA 125b-1 Neighboring gene STARR-seq mESC enhancer starr_23884 Neighboring gene predicted gene, 35835 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_23885 Neighboring gene VISTA enhancer mm1608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p. Shi L, et al. Cell Commun Signal, 2023 Sep 21. PMID 37735657, Free PMC Article
    2. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. Rowe RG, et al. J Exp Med, 2016 Jul 25. PMID 27401346, Free PMC Article
    3. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Rousseaux MW, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019375, Free PMC Article
    4. Identifying key m(6)A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses. Yang J, et al. Front Genet, 2022. PMID 36482889, Free PMC Article
    5. The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Robinton DA, et al. Dev Cell, 2019 Feb 11. PMID 30661985

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p.
      Title: Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Other Names

    • mir-100-let-7a-2 cluster host

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015483.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences, compared to variant 1.
      Source sequence(s)
      AK034222, BB871953, BE944930, CT025619
      Related
      ENSMUST00000246086.2

    2. NR_040725.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate 3' exons and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AK014147, BB625832, CT009696

    3. NR_131928.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is a non-coding transcript.
      Source sequence(s)
      AK014147, AW491891, BB625832

    4. NR_131929.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate 3' exons and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      BB625832, CT009696
      Related
      ENSMUST00000187345.7

    5. NR_131930.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1.
      Source sequence(s)
      AK084170, BE947288, BM936455, CT009696, CT025619
      Related
      ENSMUST00000181814.4

    6. NR_131931.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1.
      Source sequence(s)
      BE944930, BM936455, CT009696, CT025619

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      41287822..41526481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033153.1: Suppressed sequence

      Description
      NM_001033153.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.