SYK spleen associated tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: SYKprovided by HGNC
Official Full Name: spleen associated tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:11491
See related: Ensembl:ENSG00000165025 MIM:600085; AllianceGenome:HGNC:11491
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IMD82; p72-Syk
Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression: Broad expression in lymph node (RPKM 32.4), appendix (RPKM 24.8) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (90801600..90898549)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (102966952..103064392)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (93563882..93660831)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach.
Title: Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach.
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Title: Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy.
SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights.
Title: SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights.
DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCbeta/P66shc signaling pathway in diabetic kidney disease.
Title: DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease.
Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism.
Title: Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism.
Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis.
Title: Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis.
Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
Title: Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With a Novel CLTC::SYK Fusion.
Title: Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With a Novel CLTC::SYK Fusion.
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets.
Title: Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets.
Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase.
Title: Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase.

Submit: New GeneRIF Correction See all GeneRIFs (318)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 82 with systemic inflammation MedGen: C5543581 OMIM: 619381 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I	PubMed
Pr55(Gag)	gag	The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with SYK	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-153763 (e-PCR)
- UniSTS:177925

D10S275 (e-PCR)
- UniSTS:147992

RH48672 (e-PCR)
- UniSTS:43290

D8S2279 (e-PCR)
- UniSTS:473907

WI-18899 (e-PCR)
- UniSTS:28988

SHGC-146795 (e-PCR)
- UniSTS:175435

RH68079 (e-PCR)
- UniSTS:56400

RH120464 (e-PCR)
- UniSTS:133459

RH91425 (e-PCR)
- UniSTS:84312

D9S2062 (e-PCR)
- UniSTS:2175

RH69035 (e-PCR)
- UniSTS:21128

SYK-1 (e-PCR)
- UniSTS:513716

SYK_1884 (e-PCR)
- UniSTS:281037

STS-S80267 (e-PCR)
- UniSTS:70625

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-15 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Fc-epsilon receptor signaling pathway	TAS Traceable Author Statement more info
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in beta selection	IEA Inferred from Electronic Annotation more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lectin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to molecule of fungal origin	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-3-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lymph vessel development	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet activation	TAS Traceable Author Statement more info
involved_in positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-3 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of arachidonate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neutrophil degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin secretion by platelet	ISS Inferred from Sequence or Structural Similarity more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
part_of B cell receptor complex	IEA Inferred from Electronic Annotation more info
part_of T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IC Inferred by Curator more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase SYK

Names: spleen tyrosine kinase

NP_001128524.1

EC 2.7.10.2

NP_001167638.1

EC 2.7.10.2

NP_001167639.1

EC 2.7.10.2

NP_003168.2

EC 2.7.10.2

XP_005252204.1

EC 2.7.10.2

XP_011517248.1

EC 2.7.10.2

XP_047279765.1

EC 2.7.10.2

XP_047279766.1

EC 2.7.10.2

XP_047279767.1

EC 2.7.10.2

XP_054219627.1

EC 2.7.10.2

XP_054219628.1

EC 2.7.10.2

XP_054219629.1

EC 2.7.10.2

XP_054219630.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017046.2 RefSeqGene

Range

5090..101820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001135052.4 → NP_001128524.1 tyrosine-protein kinase SYK isoform Syk(S)

See identical proteins and their annotated locations for NP_001128524.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).

Source sequence(s)

AL354862, W33104, Z29630

Consensus CDS

CCDS47992.1

UniProtKB/TrEMBL

A8K4G2

Related

ENSP00000364904.4, ENST00000375751.8

Conserved Domains (4) summary

cd05116
Location:352 → 608

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

pfam07714
Location:351 → 603

Pkinase_Tyr; Protein tyrosine kinase
NM_001174167.3 → NP_001167638.1 tyrosine-protein kinase SYK isoform Syk(L)

See identical proteins and their annotated locations for NP_001167638.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform Syk(L).

Source sequence(s)

AL354862, BU429809, W33104, X73568

Consensus CDS

CCDS6688.1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2

Related

ENSP00000364898.1, ENST00000375746.1

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
NM_001174168.3 → NP_001167639.1 tyrosine-protein kinase SYK isoform Syk(S)

See identical proteins and their annotated locations for NP_001167639.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).

Source sequence(s)

AL354862, BC011399, BM019270, W33104

Consensus CDS

CCDS47992.1

UniProtKB/TrEMBL

A8K4G2

Related

ENSP00000364899.1, ENST00000375747.5

Conserved Domains (4) summary

cd05116
Location:352 → 608

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

pfam07714
Location:351 → 603

Pkinase_Tyr; Protein tyrosine kinase
NM_003177.7 → NP_003168.2 tyrosine-protein kinase SYK isoform Syk(L)

See identical proteins and their annotated locations for NP_003168.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (Syk(L)). Both variants 1 and 3 encode the same isoform.

Source sequence(s)

AL354862, BC001645, L28824, W33104

Consensus CDS

CCDS6688.1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2

Related

ENSP00000364907.4, ENST00000375754.9

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

90801600..90898549

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011518946.4 → XP_011517248.1 tyrosine-protein kinase SYK isoform X1

See identical proteins and their annotated locations for XP_011517248.1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_047423809.1 → XP_047279765.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2
XM_005252147.5 → XP_005252204.1 tyrosine-protein kinase SYK isoform X1

See identical proteins and their annotated locations for XP_005252204.1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_047423810.1 → XP_047279766.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A8K4G2
XM_047423811.1 → XP_047279767.1 tyrosine-protein kinase SYK isoform X3

UniProtKB/TrEMBL

C3W981

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

102966952..103064392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363653.1 → XP_054219628.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2
XM_054363652.1 → XP_054219627.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

P43405

UniProtKB/TrEMBL

A8K4G2
XM_054363654.1 → XP_054219629.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A8K4G2
XM_054363655.1 → XP_054219630.1 tyrosine-protein kinase SYK isoform X3

UniProtKB/TrEMBL

C3W981