Ctu2 cytosolic thiouridylase subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctu2provided by MGI
Official Full Name: cytosolic thiouridylase subunit 2provided by MGI
Primary source: MGI:MGI:1914215
See related: Ensembl:ENSMUSG00000049482 AllianceGenome:MGI:1914215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ncs2; C16orf84; 2310061F22Rik
Summary: Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 27.2), ovary adult (RPKM 25.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.26 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123202882..123209831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122476068..122483092)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifies an homologous human protein that plays a role in tRNA modification.
Title: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein urmylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic tRNA 2-thiolation protein 2

Names: cytosolic thiouridylase subunit 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.