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    Tcf25 transcription factor 25 (basic helix-loop-helix) [ Mus musculus (house mouse) ]

    Gene ID: 66855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcf25provided by MGI
    Official Full Name
    transcription factor 25 (basic helix-loop-helix)provided by MGI
    Primary source
    MGI:MGI:1914105
    See related
    Ensembl:ENSMUSG00000001472 AllianceGenome:MGI:1914105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nulp1; mKIAA1049; D8Ertd325e; 1100001J13Rik; 1810041K11Rik
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of protein K48-linked ubiquitination; and rescue of stalled ribosome. Located in nucleus. Is expressed in several structures, including alimentary system; bone; genitourinary system; nervous system; and skin. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 101.0), cortex adult (RPKM 91.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcf25 in Genome Data Viewer
    Location:
    8 E1; 8 72.1 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124097511..124130913)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123370772..123404174)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene Fanconi anemia, complementation group A Neighboring gene STARR-positive B cell enhancer ABC_E8971 Neighboring gene STARR-seq mESC enhancer starr_22969 Neighboring gene STARR-seq mESC enhancer starr_22970 Neighboring gene spire type actin nucleation factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125928490-125928752 Neighboring gene STARR-seq mESC enhancer starr_22972 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin, beta 3 class III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. Olsson M, et al. Cell Tissue Res, 2002 Jun. PMID 12107429
    2. NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity. Zhang X, et al. J Am Heart Assoc, 2020 Aug 18. PMID 32805187, Free PMC Article
    3. Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. Kremmidiotis G, et al. Genomics, 2001 Aug. PMID 11549317
    4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RQC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome quality control complex subunit TCF25
    Names
    nuclear localized protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037877.4 → NP_001032966.1  ribosome quality control complex subunit TCF25 isoform a

      See identical proteins and their annotated locations for NP_001032966.1

      Status: VALIDATED

      Source sequence(s)
      AC122266
      Consensus CDS
      CCDS52700.1
      UniProtKB/TrEMBL
      A0A1D5RM90
      Related
      ENSMUSP00000104468.3, ENSMUST00000108840.4
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    2. NM_001037878.5 → NP_001032967.1  ribosome quality control complex subunit TCF25 isoform c

      See identical proteins and their annotated locations for NP_001032967.1

      Status: VALIDATED

      Source sequence(s)
      AC122266
      Consensus CDS
      CCDS22755.1
      UniProtKB/Swiss-Prot
      Q3THR8, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q8R3L2, Q9CUW0, Q9ER19
      UniProtKB/TrEMBL
      A0A1D5RM90
      Related
      ENSMUSP00000056485.4, ENSMUST00000057934.10
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    3. NM_001286362.2 → NP_001273291.1  ribosome quality control complex subunit TCF25 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC122266
      Consensus CDS
      CCDS85631.1
      UniProtKB/TrEMBL
      A0A1D5RM90
      Related
      ENSMUSP00000148344.2, ENSMUST00000212470.2
      Conserved Domains (1) summary
      pfam04910
      Location:223 → 563
      Tcf25; Transcriptional repressor TCF25

    4. NM_001286363.3 → NP_001273292.1  ribosome quality control complex subunit TCF25 isoform e

      See identical proteins and their annotated locations for NP_001273292.1

      Status: VALIDATED

      Source sequence(s)
      AC122266
      UniProtKB/TrEMBL
      A0A1D5RM90, B2ZAC8
      Related
      ENSMUSP00000148454.2, ENSMUST00000212569.2
      Conserved Domains (1) summary
      pfam04910
      Location:223 → 563
      Tcf25; Transcriptional repressor TCF25

    5. NM_001359075.2 → NP_001346004.1  ribosome quality control complex subunit TCF25 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC122266
      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    6. NM_001359076.2 → NP_001346005.1  ribosome quality control complex subunit TCF25 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC122266
      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:223 → 563
      Tcf25; Transcriptional repressor TCF25

    7. NM_025804.3 → NP_080080.2  ribosome quality control complex subunit TCF25 isoform b

      See identical proteins and their annotated locations for NP_080080.2

      Status: VALIDATED

      Source sequence(s)
      BC046768, BE993156, BY080269
      Consensus CDS
      CCDS85630.1
      UniProtKB/TrEMBL
      A0A1D5RM90
      Related
      ENSMUSP00000148531.2, ENSMUST00000212571.2
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124097511..124130913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531296.5 → XP_006531359.1  ribosome quality control complex subunit TCF25 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RM90
      Related
      ENSMUSP00000148676.2, ENSMUST00000211932.2
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    2. XM_006531297.2 → XP_006531360.1  ribosome quality control complex subunit TCF25 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    3. XM_011248487.2 → XP_011246789.1  ribosome quality control complex subunit TCF25 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    4. XM_030243730.1 → XP_030099590.1  ribosome quality control complex subunit TCF25 isoform X4

      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:248 → 588
      Tcf25; Transcriptional repressor TCF25

    5. XM_006531298.4 → XP_006531361.1  ribosome quality control complex subunit TCF25 isoform X5

      UniProtKB/TrEMBL
      A0A1D5RM90
      Conserved Domains (1) summary
      pfam04910
      Location:223 → 563
      Tcf25; Transcriptional repressor TCF25
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3L2.2 GenPept UniProtKB/Swiss-Prot:Q8R3L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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