Pate4 prostate and testis expressed 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pate4provided by MGI
Official Full Name: prostate and testis expressed 4provided by MGI
Primary source: MGI:MGI:1930790
See related: Ensembl:ENSMUSG00000032099 AllianceGenome:MGI:1930790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Svs7; Pate-B; 9530004K16Rik
Summary: Predicted to enable acetylcholine receptor regulator activity. Acts upstream of or within modulation of chemical synaptic transmission and response to wounding. Predicted to be located in acrosomal vesicle and extracellular space. Is expressed in alimentary system; genitourinary system; and skin. Orthologous to human PATE4 (prostate and testis expressed 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.34 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (35518387..35523164, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35607093..35611885, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PATE4 is a novel factor in forming the copulatory plug that inhibits sequential matings and maintains spermatozoa in the uterus to ensure male fecundity.
Title: Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity†.
Taken together, our study was the first to generate and analyze a mouse model lacking Pate4, a gene with strong expression in prostate and seminal vesicles, yet without major function for fertility.
Title: No obvious phenotypic abnormalities in mice lacking the Pate4 gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490509

NoName (e-PCR)
- UniSTS:495518

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: prostate and testis expressed protein 4

Names: PATE-like protein B; SVS VII; calcium transport inhibitor; caltrin; seminal vesicle protein 7; seminal vesicle protein VII; seminal vesicle protein, secretion 7; seminal vesicle secretory protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.