ATP4 F1F0 ATP synthase subunit 4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: ATP4
Official Full Name: F1F0 ATP synthase subunit 4
Primary source: SGD:S000005999
Locus tag: YPL078C
See related: AllianceGenome:SGD:S000005999; FungiDB:YPL078C; VEuPathDB:YPL078C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPF7
Summary: Contributes to proton-transporting ATP synthase activity, rotational mechanism and proton-transporting ATPase activity, rotational mechanism. Involved in protein-containing complex assembly and proton motive force-driven ATP synthesis. Part of proton-transporting ATP synthase, stator stalk. Is active in mitochondrion. Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ATP4 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (408010..408744, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermembrane space loop of mitochondrial F1F0 ATP synthase subunit 4 is a main component of the peripheral stalk and is involved in dimerization/oligomerization of the enzyme.
Title: The intermembrane space loop of subunit b (4) is a major determinant of the stability of yeast oligomeric ATP synthases.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed
contributes_to proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase, stator stalk	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: F1F0 ATP synthase subunit 4

NP_015247.1

Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

408010..408744 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183892.1 → NP_015247.1 TPA: F1F0 ATP synthase subunit 4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015247.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3T8, E9P905, P05626, Q02830

UniProtKB/TrEMBL

A6ZWH2, B3LKZ2, B5VT84, C7GTY0, C8ZIV2, G2WPA3, N1NVH4

Conserved Domains (1) summary

pfam05405
Location:75 → 237

Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)