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    Treh trehalase (brush-border membrane glycoprotein) [ Mus musculus (house mouse) ]

    Gene ID: 58866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trehprovided by MGI
    Official Full Name
    trehalase (brush-border membrane glycoprotein)provided by MGI
    Primary source
    MGI:MGI:1926230
    See related
    Ensembl:ENSMUSG00000032098 AllianceGenome:MGI:1926230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210412M19Rik
    Summary
    This gene belongs to the alpha-glucosidase family, whose members encode enzymes that carry out hydrolysis of alpha-glucoside bonds of a variety of carbohydrates. The enzyme encoded by this gene uses the disaccharide trehalose as a highly specific substrate and converts it into two glucose molecules. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in duodenum adult (RPKM 127.9), small intestine adult (RPKM 63.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Treh in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44584530..44597602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44673233..44686305)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene cDNA sequence BC049987 Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice. Arai C, et al. Nutr Metab (Lond), 2020. PMID 32206077, Free PMC Article
    2. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Nanthakumar NN, et al. Glycobiology, 2005 Mar. PMID 15483270
    3. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redmann M, et al. Redox Biol, 2017 Apr. PMID 28068606, Free PMC Article
    4. Cloning, characterization and mapping of the mouse trehalase (Treh) gene. Oesterreicher TJ, et al. Gene, 2001 May 30. PMID 11404018
    5. Partial characterization of murine intestinal maltase-glucoamylase. Quezada-Calvillo R, et al. Biochem Biophys Res Commun, 2002 Jul 12. PMID 12150962

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha,alpha-trehalase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in trehalose catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trehalase
    Names
    alpha,alpha-trehalase
    alpha,alpha-trehalose glucohydrolase
    NP_001264776.1
    NP_001264780.1
    NP_067456.1
    XP_006510579.1
    XP_006510580.1
    XP_006510581.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277847.1 → NP_001264776.1  trehalase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site causing a frameshift in the 5' coding region, and lacks an alternate exon in the 5' coding region which corrects the frameshift, compared to variant 1. It encodes isoform 2, which is shorter and contains an alternate internal segment, compared to isoform 1.
      Source sequence(s)
      AC151971
      Consensus CDS
      CCDS72222.1
      UniProtKB/TrEMBL
      E9PYP7, Q8VCS8
      Related
      ENSMUSP00000071206.6, ENSMUST00000071219.12
      Conserved Domains (1) summary
      cl17346
      Location:138 → 512
      Trehalase; Trehalase

    2. NM_001277851.1 → NP_001264780.1  trehalase isoform 3

      See identical proteins and their annotated locations for NP_001264780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an internal exon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC151971, AK002566, BX630594
      UniProtKB/TrEMBL
      Q8VCS8
      Conserved Domains (1) summary
      cl17346
      Location:108 → 483
      Trehalase

    3. NM_021481.3 → NP_067456.1  trehalase isoform 1 precursor

      See identical proteins and their annotated locations for NP_067456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC151971, AK008912, BX630594
      Consensus CDS
      CCDS23117.1
      UniProtKB/Swiss-Prot
      Q91ZS4, Q9JLT2
      Related
      ENSMUSP00000034609.5, ENSMUST00000034609.11
      Conserved Domains (2) summary
      COG1626
      Location:19 → 551
      TreA; Neutral trehalase [Carbohydrate transport and metabolism]
      pfam01204
      Location:43 → 547
      Trehalase; Trehalase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44584530..44597602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510517.3 → XP_006510580.1  trehalase isoform X2

      See identical proteins and their annotated locations for XP_006510580.1

      UniProtKB/TrEMBL
      Q8VCS8
      Conserved Domains (1) summary
      cl17346
      Location:108 → 483
      Trehalase

    2. XM_006510516.4 → XP_006510579.1  trehalase isoform X1

      See identical proteins and their annotated locations for XP_006510579.1

      Conserved Domains (1) summary
      pfam01204
      Location:3 → 508
      Trehalase

    3. XM_006510518.4 → XP_006510581.1  trehalase isoform X2

      See identical proteins and their annotated locations for XP_006510581.1

      UniProtKB/TrEMBL
      Q8VCS8
      Conserved Domains (1) summary
      cl17346
      Location:108 → 483
      Trehalase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLT2.1 GenPept UniProtKB/Swiss-Prot:Q9JLT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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