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    THP2 Thp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THP2
    Official Full Name
    Thp2p
    Primary source
    SGD:S000001210
    Locus tag
    YHR167W
    See related
    AllianceGenome:SGD:S000001210; FungiDB:YHR167W; VEuPathDB:YHR167W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nucleic acid binding activity. Involved in several processes, including cellular response to azide; gene expression; and stress granule assembly. Part of THO complex part of transcription export complex and nucleoplasmic THO complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THP2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (439342..440127)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit PRP8 Neighboring gene anaphase promoting complex subunit CDC23 Neighboring gene putative GTPase MTG2 Neighboring gene ATP-dependent RNA helicase DBP8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. Chávez S, et al. EMBO J, 2000 Nov 1. PMID 11060033, Free PMC Article
    2. Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity. García-Rubio M, et al. Mol Genet Genomics, 2008 Feb. PMID 17960421
    3. Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. Gwizdek C, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17056718, Free PMC Article
    4. Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. Preker PJ, et al. RNA, 2006 Jun. PMID 16618971, Free PMC Article
    5. Structural characterization of the Saccharomyces cerevisiae THO complex by small-angle X-ray scattering. Poulsen JB, et al. PLoS One, 2014. PMID 25062267, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to azide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nucleoplasmic THO complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleoplasmic THO complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thp2p
    NP_012037.1
    • Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      439342..440127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179298.1 → NP_012037.1  TPA: Thp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012037.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB6, O13539
      UniProtKB/TrEMBL
      A6ZT75, B3LST1, B5VK94, C7GJX3, C8Z9W5, G2WFP1, N1P2E8
      Conserved Domains (1) summary
      pfam09432
      Location:115 → 243
      THP2; Tho complex subunit THP2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O13539.1

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