Pou2af1 POU domain, class 2, associating factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pou2af1provided by MGI
Official Full Name: POU domain, class 2, associating factor 1provided by MGI
Primary source: MGI:MGI:105086
See related: Ensembl:ENSMUSG00000032053 AllianceGenome:MGI:105086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bob1; OCAB; BOB.1; Bob-1; OBF-1; OBF.1; OCA-B
Summary: Enables DNA binding activity and transcription coactivator activity. Involved in cellular response to virus; germinal center B cell differentiation; and positive regulation of interleukin-6 production. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 91.2), mammary gland adult (RPKM 18.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.95 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (51124990..51151379)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (51213690..51240079)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OCA-B/Pou2af1 is sufficient to promote CD4[+] T cell memory and prospectively identifies memory precursors.
Title: OCA-B/Pou2af1 is sufficient to promote CD4(+) T cell memory and prospectively identifies memory precursors.
Bob1 maintains T follicular helper cells for long-term humoral immunity.
Title: Bob1 maintains T follicular helper cells for long-term humoral immunity.
T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation.
Title: T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation.
BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function.
Title: BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function.
OBF1 and Oct factors control the germinal center transcriptional program.
Title: OBF1 and Oct factors control the germinal center transcriptional program.
Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice.
Title: Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice.
Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.
Title: Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.
The Bob1 enhances IL-17A expression in vivo and in vitro by interacting with RORgammat in Th17cells, suggesting that Bob1 plays a pivotal role in Th17-mediated autoimmune disease.
Title: Bob1 enhances RORγt-mediated IL-17A expression in Th17 cells through interaction with RORγt.
Our findings demonstrate a novel role for BOB.1 in B cells during TD GC responses and suggest that its dysregulation may contribute to the pathogenesis of RA by disturbing the B cell-fate determination.
Title: BOB.1 controls memory B-cell fate in the germinal center reaction.
The number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of IgG and impaired glucose homeostasis.
Title: Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

General gene information

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Markers

Pou2af1 (e-PCR), detects polymorphism
- UniSTS:144242

Z54283 (e-PCR)
- UniSTS:163458

Pou2af1 (e-PCR), detects polymorphism
- UniSTS:536544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables POU domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germinal center B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: POU domain class 2-associating factor 1

Names: B-cell-specific coactivator OBF-1; OCT-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.