Rop Ras opposite [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ropprovided by FlyBase
Official Full Name: Ras oppositeprovided by FlyBase
Primary source: FLYBASE:FBgn0004574
Locus tag: Dmel_CG15811
See related: AllianceGenome:FB:FBgn0004574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15811; cs1; Dmel\CG15811; l(3)64Ah; l(3)SH16; ras2; rop; ROP; rop(Sec1); sec1; SEC1; Unc18
Summary: Predicted to enable syntaxin binding activity. Involved in several processes, including positive regulation of dendrite development; regulation of pole plasm oskar mRNA localization; and secretion by cell. Located in cytosol and terminal bouton. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including central nervous system; garland cell; gonad; nerve; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in West syndrome; developmental and epileptic encephalopathy 4; and familial hemophagocytic lymphohistiocytosis 5. Orthologous to several human genes including STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64A7-64A7; 3-10 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4136359..4138996, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4136359..4138996, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

furrow ingression and abscission during cytokinesis requires Rop in developing Drosophila embryos.
Title: Rop, the Sec1/Munc18 homolog in Drosophila, is required for furrow ingression and stable cell shape during cytokinesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretion by cell	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle priming	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle transport	TAS Traceable Author Statement more info	PubMed
involved_in vesicle docking involved in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed