Hsp60A Heat shock protein 60A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp60Aprovided by FlyBase
Official Full Name: Heat shock protein 60Aprovided by FlyBase
Primary source: FLYBASE:FBgn0015245
Locus tag: Dmel_CG12101
See related: AllianceGenome:FB:FBgn0015245
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 12; BP5; CG12101; cpn60; Cpn60; d-hsp60; Dm10A; Dmel\CG12101; Dmhsp60; DmHsp60; G62; Hsp 60; hsp60; Hsp60; HSP60; hsp60A; HSP60A; Hsp64; IEF16; l(1)10Ac; l(1)BP5; l(1)dp025; l(1)G8; l(1)HM21; l(1)L12; Mmp-P1; SSP 7506
Summary: Predicted to enable ATP hydrolysis activity and protein-folding chaperone binding activity. Involved in cellular response to heat and mitochondrion organization. Located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10A4-10A4; 1-33 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11108482..11112308)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11002515..11006341)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We documented how floral traits under selection by multiple pollinators can result in either an intermediate "compromise" between selective pressures (sex organs) or apparent specialization (corolla tube length) to one pollinator
Title: Selection on Polemonium brandegeei (Polemoniaceae) flowers under hummingbird pollination: in opposition, parallel, or independent of selection by hawkmoths?
Expression of HSP60A is post-transcriptionally regulated in a highly dynamic pattern during embryogenesis, even under heat-shock conditions. In contrast, in very stressful situations, its expression is upregulated transcriptionally over the entire embryo.
Title: The expression of heat shock protein HSP60A reveals a dynamic mitochondrial pattern in Drosophila melanogaster embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IEA Inferred from Electronic Annotation more info
NOT involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock protein 60A

Names: 60-kDa heat shock protein, mitochondrial; CG12101-PA; CG12101-PB; Hsp 60; Hsp60A-PA; Hsp60A-PB; heat shock protein 60; heat shock protein 60 kDa; lethal(1)10Ac; mitochondrial matrix protein P1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11108482..11112308

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078560.3 → NP_511115.2 heat shock protein 60A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511115.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4A0, O02649, P35380, Q6NR71, Q95026, Q9VZ31

UniProtKB/TrEMBL

C7LA94

Related

FBpp0073290

Conserved Domains (2) summary

PTZ00114
Location:12 → 549

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:24 → 544

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
NM_167266.1 → NP_727489.1 heat shock protein 60A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727489.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4A0, O02649, P35380, Q6NR71, Q95026, Q9VZ31

UniProtKB/TrEMBL

C7LA94

Related

FBpp0073291, FBtr0073435

Conserved Domains (2) summary

PTZ00114
Location:12 → 549

PTZ00114; Heat shock protein 60; Provisional

cd03344
Location:24 → 544

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...