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    yellow-f2 yellow-f2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yellow-f2provided by FlyBase
    Official Full Name
    yellow-f2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038105
    Locus tag
    Dmel_CG8063
    See related
    AllianceGenome:FB:FBgn0038105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8063; DCDT; DI; Dmel\CG8063; yel-f2; Yellow-f2
    Summary
    Enables dopachrome isomerase activity and dopaminechrome tautomerase activity. Involved in indole-containing compound biosynthetic process. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See yellow-f2 in Genome Data Viewer
    Location:
    87D7-87D7; 3-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12993395..12995147, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8819117..8820869, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene yellow-f Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electrochemical identification of dopachrome isomerase in Drosophila melanogaster. Li J, et al. Biochem Biophys Res Commun, 1991 Oct 31. PMID 1953745
    2. Drosophila melanogaster has the enzymatic machinery to make the melanic component of neuromelanin. Barek H, et al. Pigment Cell Melanoma Res, 2018 Nov. PMID 29741814
    3. Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes. Han Q, et al. Biochem J, 2002 Nov 15. PMID 12164780, Free PMC Article
    4. Evolution of wing pigmentation in Drosophila: Diversity, physiological regulation, and cis-regulatory evolution. Koshikawa S. Dev Growth Differ, 2020 Jun. PMID 32171022, Free PMC Article
    5. Drosophila yellow-h encodes dopaminechrome tautomerase: A new enzyme in the eumelanin biosynthetic pathway. Barek H, et al. Pigment Cell Melanoma Res, 2022 Jan. PMID 34388859

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes.
      Title: Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dopachrome isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dopaminechrome tautomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental pigmentation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in developmental pigmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in indole-containing compound biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in melanin biosynthetic process from tyrosine IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in melanin biosynthetic process from tyrosine TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    yellow-f2
    Names
    CG8063-PA
    dopachrome decarboxylase/tautomerase
    dopachrome isomerase
    yellow-f2-PA
    NP_650247.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12993395..12995147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141990.3 → NP_650247.1  yellow-f2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SK7, Q9VG08
      Related
      FBpp0082190
      Conserved Domains (1) summary
      pfam03022
      Location:163 → 451
      MRJP; Major royal jelly protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG08.2 Q9VG08

    Gene LinkOut

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