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    St4 Sulfotransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St4provided by FlyBase
    Official Full Name
    Sulfotransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0033887
    Locus tag
    Dmel_CG6704
    See related
    AllianceGenome:FB:FBgn0033887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6704; Dmel\CG6704; dmST4; st4
    Summary
    Enables sulfotransferase activity. Involved in sulfation and xenobiotic metabolic process. Predicted to be active in cytoplasm. Is expressed in embryonic esophagus; embryonic/larval pharynx; embryonic/larval tracheal dorsal trunk; and organism. Orthologous to human SULT4A1 (sulfotransferase family 4A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See St4 in Genome Data Viewer
    Location:
    50C20-50C20; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13969910..13971263, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9857415..9858768, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cathepsin L1 Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and characterization of cytosolic sulfotransferase isozymes from Drosophila melanogaster. Hattori K, et al. Biosci Biotechnol Biochem, 2008 Feb. PMID 18256476
    2. Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila. Fahmy K, et al. Hereditas, 2013 Jun. PMID 23865965
    3. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article
    4. Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. Short SM, et al. G3 (Bethesda), 2013 May 20. PMID 23550122, Free PMC Article
    5. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfotransferase 4
    Names
    CG6704-PA
    CG6704-PB
    St4-PA
    St4-PB
    NP_001286398.1
    NP_610918.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13969910..13971263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299469.1 → NP_001286398.1  sulfotransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9J8, F0JAQ0
      Conserved Domains (1) summary
      pfam00685
      Location:62 → 311
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_137074.3 → NP_610918.1  sulfotransferase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9J8, F0JAQ0
      Related
      FBpp0086735
      Conserved Domains (1) summary
      pfam00685
      Location:62 → 311
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9J8 A1Z9J8

    Gene LinkOut

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