Atpalpha Na pump alpha subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atpalphaprovided by FlyBase
Official Full Name: Na pump alpha subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0002921
Locus tag: Dmel_CG5670
See related: AllianceGenome:FB:FBgn0002921
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: (Na[+]/k[+])-ATPase; alpha-ATPase; Atp; Atp a; ATP-alpha; Atpa; ATPa; atpalpha; ATPalpha; ATPalpha1; ATPBagr; CG5670; Da-47; Dmel\CG5670; dnATPase; JY; K ATPase; K-ATPase; K[+] -ATPase; K[+]-ATPase; K[+]-ATPase alpha subunit; K[+]-ATPase alpha-subunit; l(3)01164; l(3)01453; l(3)04492; l(3)j3B2; l(3)j3B7; l(3)j6A4; l(3)rM454; l(3)ry136; Na; Na+-K+-ATPase; Na+/K+ ATPase alpha subunit; Na+/K+-ATPase; Na-p; Na/K ATPase; Na/K-ATPase; Na/K-ATPase alpha-subunit; NaK; NaK ATPase; NaK-ATPase; Na[+]; Na[+]-K[+]-ATPase alpha[[5]]-subunit; Na[+]/K[+] ATPase; Na[+]/K[+]-ATPase; Na[+]/K[+]ATPase; Na[+]K[+] ATPase; Na[+]K[+]-ATPase; Na[+]K[+]ATPase; Na[+]K[+]ATPase-alpha; NKA; sodium/potassium transporting ATPase alpha
Summary: Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including cell junction assembly; determination of adult lifespan; and respiratory system development. Located in basolateral plasma membrane; nucleus; and septate junction. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including brain; epithelial cell; organism subdivision; salivary gland; and synaptic neuropil domain. Used to study Charcot-Marie-Tooth disease type 2DD; epilepsy; familial hemiplegic migraine; and nervous system disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; bipolar disorder; brain disease (multiple); and hypertension. Orthologous to several human genes including ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93A4-93A4; 3-69 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20948714..20976239)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16774436..16801961)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila endogenously expresses Dube3a (fly UBE3A homolog) in glial cells and neurons. A robust seizure-like phenotype was observed in flies overexpressing Dube3a in glial cells, but not neurons. Glial-specific knockdown of ATPalpha also produced seizure-like behavior, and this phenotype was rescued by simultaneously overexpressing ATPalpha and Dube3a in glia.
Title: Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na(+)/K(+) pump ATPα.
genome-wide screen to find regions of the genome containing elements important for genetic modulation of ATPalpha dysfunction, were identified.
Title: Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci.
Data suggest that the sodium/potassium pump Na+/K+-ATPase alpha subunit may be a key target of the circadian pacemaker to impose daily control on brain activities.
Title: Circadian regulation of the Na+/K+-ATPase alpha subunit in the visual system is mediated by the pacemaker and by retina photoreceptors in Drosophila melanogaster.
analysis of a series of new missense alleles of ATPalpha in Drosophila
Title: Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.
Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins
Title: Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.
Gene expression of the alpha-subunit of Na+/K+-ATPase showed a robust daily rhythm in concentration changes.
Title: Cyclical expression of Na+/K+-ATPase in the visual system of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1677 (e-PCR)
- UniSTS:61002

Dm1874 (e-PCR)
- UniSTS:1762

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in jump response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tube diameter, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Na pump alpha subunit

Names: (Na[+] + K[+])-ATPase alpha-subunit; (Na[+],K[+])ATPase alpha subunit; ATPalpha; ATPase alpha; ATPase alpha subunit; Atpalpha-PA; Atpalpha-PB; Atpalpha-PC; Atpalpha-PD; Atpalpha-PE; Atpalpha-PF; Atpalpha-PG; Atpalpha-PH; Atpalpha-PI; Atpalpha-PJ; Atpalpha-PK; CG5670-PA; CG5670-PB; CG5670-PC; CG5670-PD; CG5670-PE; CG5670-PF; CG5670-PG; CG5670-PH; CG5670-PI; CG5670-PJ; CG5670-PK; Na+,K+ ATPase alpha-subunit; Na+K+ ATPase alpha subunit; Na, K ATPase a subunit; Na,K ATPase; Na,K ATPase alpha subunit; Na,K-ATPase; Na,K-ATPase alpha; Na,K-ATPase alpha subunit; Na,K-ATPase alpha-subunit; NaK-ATPase; Na[ +], K[ +] -ATPase; Na[+] pump alpha subunit; Na[+], K[+] ATPase alpha; Na[+],K[+] ATPase alpha subunit; Na[+],K[+]-ATPase alpha subunit; Na[+]-K[+] ATPase; Na[+]/K[+] ATPase (alpha subunit); Na[+]/K[+] ATPase alpha subunit; Na[+]/K[+]-ATPase; Na[+]K[+] ATPase alpha subunit; Na[+]K[+]ATPase; alpha-subunit of ATPase; sodium pump alpha subunit; sodium pump alpha-subunit

NP_001163667.1

EC 7.2.2.13

EC 7.2.2.6

NP_001262790.1

EC 7.2.2.13

EC 7.2.2.6

NP_001262791.1

EC 7.2.2.13

EC 7.2.2.6

NP_732572.1

EC 7.2.2.13

EC 7.2.2.6

NP_732573.1

EC 7.2.2.13

EC 7.2.2.6

NP_732574.1

EC 7.2.2.13

EC 7.2.2.6

NP_732575.1

EC 7.2.2.13

EC 7.2.2.6

NP_996247.1

EC 7.2.2.13

EC 7.2.2.6

NP_996248.1

EC 7.2.2.13

EC 7.2.2.6

NP_996249.1

EC 7.2.2.13

EC 7.2.2.6

NP_996250.1

EC 7.2.2.13

EC 7.2.2.6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20948714..20976239

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275861.1 → NP_001262790.1 Na pump alpha subunit, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262790.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG8, C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_001170196.3 → NP_001163667.1 Na pump alpha subunit, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163667.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VUY7, E1JIR4, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_169938.3 → NP_732574.1 Na pump alpha subunit, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732574.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG8, C8VUY7, I7J4E4

Related

FBpp0088501

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_206527.3 → NP_996249.1 Na pump alpha subunit, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996249.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_206526.3 → NP_996248.1 Na pump alpha subunit, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996248.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_001275862.2 → NP_001262791.1 Na pump alpha subunit, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262791.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG8, C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_169936.3 → NP_732572.1 Na pump alpha subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732572.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V366, A4V367, O61494, P13607, Q0KI37, Q7KS94, Q7KS95, Q86MY6, Q86MY7, Q86MY8, Q86MY9, Q86MZ0, Q8IN40, Q8T0L8, Q9VDG6, Q9VDG7, Q9VDG8

UniProtKB/TrEMBL

C8VUY7, H9ZJM5, I7J4E4

Related

FBpp0088502

Conserved Domains (6) summary

smart00831
Location:58 → 132

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:695 → 770

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:45 → 1041

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:152 → 383

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:817 → 1025

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:445 → 539

Cation_ATPase; Cation transport ATPase (P-type)
NM_206528.3 → NP_996250.1 Na pump alpha subunit, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996250.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG8, C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_169939.2 → NP_732575.1 Na pump alpha subunit, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732575.1

Status: REVIEWED

UniProtKB/TrEMBL

B5RIT8, E6PBW0

Related

FBpp0088504

Conserved Domains (5) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01494
Location:114 → 787

ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_206525.3 → NP_996247.1 Na pump alpha subunit, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996247.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VUY7, I7J4E4

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)
NM_169937.3 → NP_732573.1 Na pump alpha subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732573.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG8, C8VUY7, I7J4E4

Related

FBpp0088503

Conserved Domains (6) summary

smart00831
Location:19 → 93

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:656 → 731

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:6 → 1002

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:113 → 344

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:778 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:406 → 500

Cation_ATPase; Cation transport ATPase (P-type)