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    Utx Utx histone demethylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Utxprovided by FlyBase
    Official Full Name
    Utx histone demethylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260749
    Locus tag
    Dmel_CG5640
    See related
    AllianceGenome:FB:FBgn0260749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-31BCa; CG5640; Dmel\CG5640; dUtx; dUTX; utx; UTX
    Summary
    Enables histone H3K27me2/H3K27me3 demethylase activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Involved in several processes, including autophagic cell death; cellular response to gamma radiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus and polytene chromosome interband. Part of MLL3/4 complex. Colocalizes with euchromatin. Is expressed in organism and pole plasm. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; Stolerman neurodevelopmental syndrome; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to several human genes including KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Utx in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10272325..10278811, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10272325..10278811, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multi-substrate lipid kinase Neighboring gene trunk Neighboring gene uncharacterized protein Neighboring gene Ubiquitin fusion-degradation 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder. Rots D, et al. Am J Hum Genet, 2023 Jun 1. PMID 37196654, Free PMC Article
    2. A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals. Rickels R, et al. Genes Dev, 2020 Nov 1. PMID 33033055, Free PMC Article
    3. Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila. Copur Ö, et al. Genetics, 2018 Feb. PMID 29247011, Free PMC Article
    4. Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila. Guida MC, et al. Nat Commun, 2019 Jan 14. PMID 30643137, Free PMC Article
    5. Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA. Laprell F, et al. Science, 2017 Apr 7. PMID 28302792

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. specific regulation of ku80 expression by UTX
      Title: Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.
    2. UTX is required for larval salivary gland cell death.UTX coordinates steroid hormone-mediated autophagy and cell death.
      Title: UTX coordinates steroid hormone-mediated autophagy and cell death.
    3. Utx do not regulate cell proliferation in Drosophila as Utx mutant cells generated in wild-type animals proliferate like wild-type cells.
      Title: The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.
    4. dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
      Title: Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
    5. Data suggest that UTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila melanogaster and may provide a model for UTX-dependent tumorigenesis in humans.
      Title: The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex comb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Utx histone demethylase
    Names
    CG5640-PA
    CG5640-PB
    CG5640-PC
    CG5640-PD
    CG5640-PE
    Utx-PA
    Utx-PB
    Utx-PC
    Utx-PD
    Utx-PE
    anon-31BCa
    ubiquitously transcribed X chromosome tetratricopeptide repeat protein
    ubiquitously transcribed tetratricopetide repeat gene on the X chromosome
    NP_001188773.1
    NP_001260319.1
    NP_609368.3
    NP_723550.2
    NP_723551.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10272325..10278811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164907.4 → NP_723550.2  Utx histone demethylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723550.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q76NQ3
      Related
      FBpp0079665
      Conserved Domains (4) summary
      pfam02373
      Location:673 → 781
      JmjC; JmjC domain, hydroxylase
      sd00006
      Location:110 → 137
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:143 → 176
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:142 → 205
      TPR_11; TPR repeat

    2. NM_001201844.1 → NP_001188773.1  Utx histone demethylase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRG4
      Conserved Domains (4) summary
      pfam02373
      Location:864 → 972
      JmjC; JmjC domain, hydroxylase
      sd00006
      Location:307 → 334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340 → 373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:339 → 402
      TPR_11; TPR repeat

    3. NM_135524.4 → NP_609368.3  Utx histone demethylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609368.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQK3, Q9VL07, Q9VL08
      Related
      FBpp0079664
      Conserved Domains (4) summary
      pfam02373
      Location:870 → 978
      JmjC; JmjC domain, hydroxylase
      sd00006
      Location:307 → 334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340 → 373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:339 → 402
      TPR_11; TPR repeat

    4. NM_164908.4 → NP_723551.2  Utx histone demethylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723551.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q76NQ3
      Related
      FBpp0079666
      Conserved Domains (4) summary
      pfam02373
      Location:673 → 781
      JmjC; JmjC domain, hydroxylase
      sd00006
      Location:110 → 137
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:143 → 176
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:142 → 205
      TPR_11; TPR repeat

    5. NM_001273390.1 → NP_001260319.1  Utx histone demethylase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCJ7
      Conserved Domains (4) summary
      pfam02373
      Location:668 → 776
      JmjC; JmjC domain, hydroxylase
      sd00006
      Location:110 → 137
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:143 → 176
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:142 → 205
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRG4 M9MRG4
    M9PCJ7 M9PCJ7
    Q76NQ3 Q76NQ3
    Q9VL07 Q9VL07

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