U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sphe spheroide [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32648, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    spheprovided by FlyBase
    Official Full Name
    spheroideprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030774
    Locus tag
    Dmel_CG9675
    See related
    AllianceGenome:FB:FBgn0030774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST153; anon-WO0140519.154; CG9675; Dmel\CG9675; SPH114; Sphe; Spheroide
    Summary
    Involved in Toll receptor ligand protein activation cascade; defense response to other organism; and positive regulation of antibacterial peptide biosynthetic process. Predicted to be located in extracellular region. Is expressed in embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sphe in Genome Data Viewer
    Location:
    15A1-15A2; 1-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16700446..16701972, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16594479..16596005, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Septin 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria. Patrnogic J, et al. PLoS One, 2017. PMID 29211760, Free PMC Article
    2. Anthrax toxin component, Protective Antigen, protects insects from bacterial infections. Alameh S, et al. PLoS Pathog, 2020 Aug. PMID 32866212, Free PMC Article
    3. Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC. Kurata S. Int Immunol, 2010 Mar. PMID 20089584, Free PMC Article
    4. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
    5. Association of Wolbachia with Gene Expression in Drosophila Testes. Dou W, et al. Microb Ecol, 2021 Oct. PMID 33555369

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    spheroide
    Names
    CG9675-PA
    sphe-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16700446..16701972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132920.3 → NP_573148.2  spheroide [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573148.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MST8, Q9VXC8
      Related
      FBpp0074137
      Conserved Domains (2) summary
      smart00020
      Location:42 → 244
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXC8 Q9VXC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools