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    Sec61beta Sec61 beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec61betaprovided by FlyBase
    Official Full Name
    Sec61 beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010638
    Locus tag
    Dmel_CG10130
    See related
    AllianceGenome:FB:FBgn0010638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10130; Dmel\CG10130; dSec61beta; DSec61beta; l(2)07214; Sec1; Sec61; sec61b; Sec61b; Sec61B; sec61beta; Secbeta61
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of autophagy. Located in endomembrane system. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; epidermis; gut section; and mesoderm. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec61beta in Genome Data Viewer
    Location:
    51B6-51B6; 2-72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14618771..14619681)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10506276..10507186)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Su(var)2-HP2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene U snoRNA host gene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid subcellular calcium responses and dynamics by calcium sensor G-CatchER(). Reddish FN, et al. iScience, 2021 Mar 19. PMID 33665552, Free PMC Article
    2. Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER. Chorlay A, et al. Dev Cell, 2019 Jul 1. PMID 31155466
    3. Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. Valcárcel R, et al. J Cell Sci, 1999 Dec. PMID 10564656
    4. The effects of ER morphology on synaptic structure and function in Drosophila melanogaster. Summerville JB, et al. J Cell Sci, 2016 Apr 15. PMID 26906425, Free PMC Article
    5. The Drosophila Nesprin-1 homolog MSP300 is required for muscle autophagy and proteostasis. van der Graaf K, et al. J Cell Sci, 2024 Jun 1. PMID 38757366, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec61 translocon complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sec61 beta subunit
    Names
    CG10130-PA
    Sec61beta-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14618771..14619681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143780.4 → NP_652037.1  Sec61 beta subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652037.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZN0
      Related
      FBpp0086627
      Conserved Domains (1) summary
      pfam03911
      Location:58 → 95
      Sec61_beta; Sec61beta family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZN0 Q7JZN0
    Q8SXW0 Q8SXW0

    Gene LinkOut

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