PIG-T Phosphatidylinositol glycan anchor biosynthesis class T [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PIG-Tprovided by FlyBase
Official Full Name: Phosphatidylinositol glycan anchor biosynthesis class Tprovided by FlyBase
Primary source: FLYBASE:FBgn0030035
Locus tag: Dmel_CG11190
See related: AllianceGenome:FB:FBgn0030035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11190; Dm*AAF46367/27-522; Dmel\CG11190; DmPIG-T; PIGT
Summary: Predicted to be involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; embryonic midline of ventral nerve cord; embryonic/larval midgut; follicle cell; and imaginal disc. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8404535..8407263, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8298568..8301296, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of GPI-anchor transamidase complex	IEA Inferred from Electronic Annotation more info
part_of GPI-anchor transamidase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed

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