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    Nadsyn NAD synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32328, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nadsynprovided by FlyBase
    Official Full Name
    NAD synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030512
    Locus tag
    Dmel_CG9940
    See related
    AllianceGenome:FB:FBgn0030512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    145027_at; CG9940; Dmel\CG9940; NADS; NADSYN; Q9VYA0
    Summary
    Predicted to enable NAD+ synthase (glutamine-hydrolyzing) activity and glutaminase activity. Involved in negative regulation of neuromuscular synaptic transmission. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nadsyn in Genome Data Viewer
    Location:
    12B2-12B4; 1-45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13684380..13718285, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13578413..13612318, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nna1 carboxypeptidase Neighboring gene Mahogunin ring finger 1 Neighboring gene mutagen-sensitive 101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression of CG9940 affects the adaptation of cardiac function, mobility, and lifespan to exercise in aging Drosophila. Wen DT, et al. Exp Gerontol, 2016 Oct. PMID 27448710
    2. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. Russo A, et al. EMBO Rep, 2019 Mar. PMID 30692130, Free PMC Article
    3. Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heart salt-specific overexpression in Drosophila. Wen DT, et al. Aging (Albany NY), 2021 Aug 12. PMID 34383711, Free PMC Article
    4. Reconstructing eukaryotic NAD metabolism. Rongvaux A, et al. Bioessays, 2003 Jul. PMID 12815723
    5. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD synthetase
    Names
    CG9940-PA
    CG9940-PB
    CG9940-PC
    NAD[+]synthase
    Nadsyn-PA
    Nadsyn-PB
    Nadsyn-PC
    NP_001285224.1
    NP_572913.1
    NP_727727.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13684380..13718285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167378.2 → NP_727727.1  NAD synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4E7, Q8IH17, Q9VYA0
      UniProtKB/TrEMBL
      C5WLN1
      Related
      FBpp0073675
      Conserved Domains (1) summary
      PLN02339
      Location:3 → 695
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    2. NM_132685.2 → NP_572913.1  NAD synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4E7, Q8IH17, Q9VYA0
      UniProtKB/TrEMBL
      C5WLN1
      Related
      FBpp0073676
      Conserved Domains (1) summary
      PLN02339
      Location:3 → 695
      PLN02339; NAD+ synthase (glutamine-hydrolysing)

    3. NM_001298295.1 → NP_001285224.1  NAD synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4E7, Q8IH17, Q9VYA0
      UniProtKB/TrEMBL
      C5WLN1
      Conserved Domains (1) summary
      PLN02339
      Location:3 → 695
      PLN02339; NAD+ synthase (glutamine-hydrolysing)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C5WLN1 C5WLN1
    Q9VYA0.1 Q9VYA0

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