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    Mnr Membrane-bound Notch regulator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mnrprovided by FlyBase
    Official Full Name
    Membrane-bound Notch regulatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052521
    Locus tag
    Dmel_CG32521
    See related
    AllianceGenome:FB:FBgn0052521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1726; CG1735; CG32521; Dmel\CG32521; mnr
    Summary
    Involved in positive regulation of Notch signaling pathway. Located in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mnr in Genome Data Viewer
    Location:
    19F2-19F3; 1-65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21205310..21281171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21076337..21152198, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene central complex broad Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Isoleucine-AAT 2-1 pseudogene Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Arginine-TCG 2-2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-1007 stem loop Neighboring gene ATP binding cassette subfamily A member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. Huang W, et al. Genome Res, 2014 Jul. PMID 24714809, Free PMC Article
    2. The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity in Drosophila melanogaster. Nagel AC, et al. Biomolecules, 2021 Nov 10. PMID 34827670, Free PMC Article
    3. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Ostrin EJ, et al. Genome Res, 2006 Apr. PMID 16533912, Free PMC Article
    4. Genome ARTIST_v2-An Autonomous Bioinformatics Tool for Annotation of Natural Transposons in Sequenced Genomes. Ecovoiu AA, et al. Int J Mol Sci, 2022 Oct 21. PMID 36293549, Free PMC Article
    5. Fine-tuning enhancer models to predict transcriptional targets across multiple genomes. Aerts S, et al. PLoS One, 2007 Nov 7. PMID 17973026, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity in Drosophila melanogaster.
      Title: The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c21216501-21216041 mobile_element_type = transposon:INE-1{}6048
    • Loc: c21272333-21272173 mobile_element_type = transposon:INE-1{}6050

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Membrane-bound notch regulator
    Names
    CG32521-PA
    CG32521-PB
    CG32521-PC
    CG32521-PD
    CG32521-PE
    CG32521-PF
    CG32521-PG
    CG32521-PH
    CG32521-PI
    Mnr-PA
    Mnr-PB
    Mnr-PC
    Mnr-PD
    Mnr-PE
    Mnr-PF
    Mnr-PG
    Mnr-PH
    Mnr-PI
    membrane-bound notch regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21205310..21281171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167734.2 → NP_728397.1  Membrane-bound notch regulator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RN65, Q9VRF7
      Related
      FBpp0076928

    2. NM_167735.2 → NP_728398.1  Membrane-bound notch regulator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RN65, Q9VRF7
      Related
      FBpp0076929

    3. NM_001272833.1 → NP_001259762.1  Membrane-bound notch regulator, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI18

    4. NM_001272828.1 → NP_001259757.1  Membrane-bound notch regulator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RN65, Q9VRF7

    5. NM_001272831.1 → NP_001259760.1  Membrane-bound notch regulator, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHP6

    6. NM_001272832.2 → NP_001259761.1  Membrane-bound notch regulator, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI38

    7. NM_001272829.1 → NP_001259758.1  Membrane-bound notch regulator, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJS2

    8. NM_001272830.1 → NP_001259759.1  Membrane-bound notch regulator, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRF8

    9. NM_167736.3 → NP_728399.1  Membrane-bound notch regulator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRF8
      Related
      FBpp0076930
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHP6 M9PHP6
    M9PI18 M9PI18
    M9PI38 M9PI38
    M9PJS2 M9PJS2
    Q8SWZ2 Q8SWZ2
    Q9VRF7 Q9VRF7
    Q9VRF8 Q9VRF8

    Gene LinkOut

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