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    CSN8 COP9 signalosome subunit 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSN8provided by FlyBase
    Official Full Name
    COP9 signalosome subunit 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0261437
    Locus tag
    Dmel_CG42522
    See related
    AllianceGenome:FB:FBgn0261437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13383; CG33297; CG42522; CH8; csn8; Csn8; Dch8; Dmel\CG42522; l(2)SH1829; l(2)SH2 1829
    Old locus tag
    Dmel_CG13383
    Summary
    Involved in several processes, including COP9 signalosome assembly; protein deneddylation; and protein stabilization. Part of COP9 signalosome. Is expressed in adult heart and organism. Orthologous to human COPS8 (COP9 signalosome subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CSN8 in Genome Data Viewer
    Location:
    29B2-29B2; 2-31 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8364855..8365663)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8364855..8365663)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S13 Neighboring gene Protein phosphatase 2A at 29B Neighboring gene antisense RNA:CR45341 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster. Nowak SJ, et al. Mol Cell Biol, 2003 Sep. PMID 12917335, Free PMC Article
    2. CellProfiler Analyst: data exploration and analysis software for complex image-based screens. Jones TR, et al. BMC Bioinformatics, 2008 Nov 15. PMID 19014601, Free PMC Article
    3. The COP9 signalosome: more than a protease. Wei N, et al. Trends Biochem Sci, 2008 Dec. PMID 18926707
    4. Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development. Oren-Giladi P, et al. Genes Cells, 2008 Mar. PMID 18298797
    5. Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Oron E, et al. Mol Syst Biol, 2007. PMID 17486136, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome subunit 8
    Names
    CG42522-PB
    COP9 complex homolog subunit 8
    CSN8-PB
    drosophila COP9 signalosome homolog 8
    lethal (2) SH1829

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8364855..8365663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164809.5 → NP_723378.2  COP9 signalosome subunit 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723378.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8L3, Q7KTH8
      Conserved Domains (1) summary
      pfam10075
      Location:22 → 156
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTH8.1 Q7KTH8

    Gene LinkOut

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