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    Arc2 Activity-regulated cytoskeleton associated protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arc2provided by FlyBase
    Official Full Name
    Activity-regulated cytoskeleton associated protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033928
    Locus tag
    Dmel_CG13941
    See related
    AllianceGenome:FB:FBgn0033928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.456; BcDNA:SD11637; CG13941; dArc2; dARC2; Dmel\CG13941
    Summary
    Enables structural molecule activity. Located in extracellular vesicle and virus-like capsid. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arc2 in Genome Data Viewer
    Location:
    50F6-50F6; 2-70 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14361924..14362825)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10249429..10250330)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Activity-regulated cytoskeleton associated protein 1 Neighboring gene pseudo Neighboring gene Transcription factor B1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. Eriksen MS, et al. Acta Physiol (Oxf), 2022 Nov. PMID 36073248, Free PMC Article
    2. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Hallin EI, et al. PLoS One, 2021. PMID 33989344, Free PMC Article
    3. Intercellular Communication in the Nervous System Goes Viral. Hantak MP, et al. Trends Neurosci, 2021 Apr. PMID 33485691, Free PMC Article
    4. Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. Erlendsson S, et al. Nat Neurosci, 2020 Feb. PMID 31907439, Free PMC Article
    5. Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Ashley J, et al. Cell, 2018 Jan 11. PMID 29328915, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
      Title: Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.
    2. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains
      Title: Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in virus-like capsid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Activity-regulated cytoskeleton associated protein 2
    Names
    Arc2-PA
    CG13941-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14361924..14362825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137112.2 → NP_610956.1  Activity-regulated cytoskeleton associated protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JV70
      Related
      FBpp0086675
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JV70.1 Q7JV70

    Gene LinkOut

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