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    sti sticky [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stiprovided by FlyBase
    Official Full Name
    stickyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002466
    Locus tag
    Dmel_CG10522
    See related
    AllianceGenome:FB:FBgn0002466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.388; CG10522; cit; CIT; CIT-K; Citron K; ck; dck; DCK; Dmel\CG10522; l(3)7m-62; l(3)7m62; l(3)SG21; STI; sti/Citron
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; negative regulation of hippo signaling; and regulation of cell cycle process. Located in actomyosin contractile ring. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and neuroblasts. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sti in Genome Data Viewer
    Location:
    69C4-69C4; 3-38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12507998..12514815, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12501098..12507915, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene vihar Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch Neighboring gene Gcn5 acetyltransferase Neighboring gene verrocchio

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. Bauer CR, et al. BMC Syst Biol, 2008 Nov 25. PMID 19032789, Free PMC Article
    2. Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation. El-Amine N, et al. Mol Biol Cell, 2019 Aug 1. PMID 31166845, Free PMC Article
    3. Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. El Amine N, et al. J Cell Biol, 2013 Nov 11. PMID 24217622, Free PMC Article
    4. Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. Dean SO, et al. PLoS One, 2006 Dec 27. PMID 17205135, Free PMC Article
    5. Citron kinase controls a molecular network required for midbody formation in cytokinesis. Bassi ZI, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716662, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
      Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
    2. Data show that Sticky (Sti), tile ring component Citron kinase (CIT-K) interacts directly with two kinesins, Nebbish and Pavarotti and that in turn these kinesins interact with each other and with another central spindle protein, Fascetto.
      Title: Citron kinase controls a molecular network required for midbody formation in cytokinesis.
    3. The Sti/CIT-K maintains correct RhoA localization at the cleavage site, which is necessary for proper RhoA activity and contractile ring dynamics.
      Title: Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis.
    4. sticky mutations can dominantly suppress a dFmr1 gain-of-function phenotype in the developing eye, while phenotypes produced by RNAi knock-down of sticky were enhanced by dFmr1 RNAi and a dFmr1 loss-of-function mutation
      Title: Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.
    5. citron kinase has a critical role in the final steps of cytokinesis
      Title: Drosophila citron kinase is required for the final steps of cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sticky
    Names
    CG10522-PA
    CG10522-PB
    citron
    citron kinase
    drosophila citron kinase
    sti-PA
    sti-PB
    NP_001261768.1
    NP_648584.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12507998..12514815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140327.2 → NP_648584.1  sticky, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTY8
      Related
      FBpp0075702
      Conserved Domains (4) summary
      smart00220
      Location:113 → 379
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:483 → 1218
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd05601
      Location:111 → 448
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00780
      Location:1499 → 1770
      CNH; CNH domain

    2. NM_001274839.1 → NP_001261768.1  sticky, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI41
      Conserved Domains (4) summary
      smart00220
      Location:113 → 383
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:487 → 1222
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00780
      Location:1503 → 1774
      CNH; CNH domain
      cl21453
      Location:111 → 452
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI41 M9PI41
    Q6NR17 Q6NR17
    Q9VTY8 Q9VTY8

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