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    PpD3 Protein phosphatase D3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PpD3provided by FlyBase
    Official Full Name
    Protein phosphatase D3provided by FlyBase
    Primary source
    FLYBASE:FBgn0005777
    Locus tag
    Dmel_CG8402
    See related
    AllianceGenome:FB:FBgn0005777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8402; D3; Dmel\CG8402; DmPP5; DmPpp5-85E; pp5; PP5; PP5 85E; Pp5-85E
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including adult brain; adult head; embryonic/larval midgut primordium; germline cell; and gut section. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PpD3 in Genome Data Viewer
    Location:
    85E6-85E6; 3-49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9747875..9751094)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5573597..5576816)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Telo2 interacting protein 1 Neighboring gene Regulatory particle triple-A ATPase 3-related Neighboring gene Alg12 alpha-1,6-mannosyltransferase Neighboring gene Mannose phosphate isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila protein phosphatase 5 is encoded by a single gene that is most highly expressed during embryonic development. Brown L, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 10899584
    2. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Silverstein AM, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904383, Free PMC Article
    3. Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival. Hayne M, et al. Neurobiol Dis, 2022 Feb. PMID 34923110, Free PMC Article
    4. Novel protein serine/threonine phosphatases: variety is the spice of life. Cohen PT. Trends Biochem Sci, 1997 Jul. PMID 9255065
    5. Plk4 Is a Novel Substrate of Protein Phosphatase 5. Ábrahám E, et al. Int J Mol Sci, 2023 Jan 19. PMID 36768356, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plk4 Is a Novel Substrate of Protein Phosphatase 5.
      Title: Plk4 Is a Novel Substrate of Protein Phosphatase 5.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase D3
    Names
    CG8402-PA
    CG8402-PB
    CG8402-PC
    PpD3-PA
    PpD3-PB
    PpD3-PC
    protein phosphatase from PCR fragment D3
    NP_001262433.1
    NP_524946.1
    NP_731398.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9747875..9751094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080207.3 → NP_524946.1  protein phosphatase D3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q26244, Q9VH81
      Related
      FBpp0081606
      Conserved Domains (5) summary
      smart00156
      Location:226 → 502
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:49 → 77
      TPR; TPR repeat [structural motif]
      cd07417
      Location:198 → 513
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam00515
      Location:49 → 81
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49 → 114
      TPR_11; TPR repeat

    2. NM_169307.2 → NP_731398.1  protein phosphatase D3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q26244, Q9VH81
      Related
      FBpp0081607
      Conserved Domains (5) summary
      smart00156
      Location:226 → 502
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:49 → 77
      TPR; TPR repeat [structural motif]
      cd07417
      Location:198 → 513
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam00515
      Location:49 → 81
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49 → 114
      TPR_11; TPR repeat

    3. NM_001275504.2 → NP_001262433.1  protein phosphatase D3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q26244, Q9VH81
      Conserved Domains (5) summary
      smart00156
      Location:226 → 502
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:49 → 77
      TPR; TPR repeat [structural motif]
      cd07417
      Location:198 → 513
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam00515
      Location:49 → 81
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49 → 114
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JPU1 Q7JPU1
    Q9VH81 Q9VH81

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