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    nSyb neuronal Synaptobrevin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38196, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nSybprovided by FlyBase
    Official Full Name
    neuronal Synaptobrevinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013342
    Locus tag
    Dmel_CG17248
    See related
    AllianceGenome:FB:FBgn0013342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17248; Dmel\CG17248; Dn-syb; n-syb; n-Syb; n-SYB; N-syb; N-Syb; N-SYB; nsyb; nSYB; Nsyb; NSYB; syb; Syb; SYB; Syb62A; VAMP
    Summary
    Enables SNAP receptor activity and SNARE binding activity. Involved in positive regulation of vesicle fusion; synaptic vesicle exocytosis; and vesicle fusion. Located in plasma membrane; synaptic vesicle; and terminal bouton. Part of SNARE complex. Is active in early endosome membrane and synaptic vesicle membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including abdominal 1 ventral longitudinal muscle cell; adult brain cell body rind; ganglia; neuron projection bundle; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to several human genes including VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nSyb in Genome Data Viewer
    Location:
    62A9-62A9; 3-0.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1630348..1637752, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1630348..1637752, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 2 Neighboring gene Big brother

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila. Eichler K, et al. Elife, 2024 Apr 18. PMID 38634460, Free PMC Article
    2. Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. Sarantseva S, et al. PLoS One, 2009 Dec 7. PMID 19997607, Free PMC Article
    3. A genetic model of methionine restriction extends Drosophila health- and lifespan. Parkhitko AA, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34588310, Free PMC Article
    4. Effect of juxtamembrane tryptophans on the immersion depth of Synaptobrevin, an integral vesicle membrane protein. Al-Abdul-Wahid MS, et al. Biochim Biophys Acta, 2012 Dec. PMID 22846509
    5. A functionally ordered visual feature map in the Drosophila brain. Klapoetke NC, et al. Neuron, 2022 May 18. PMID 35290791

    See all (349) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data indicate that juxtamembrane tryptophan residues are important determinants of the position of Synaptobrevin in the membrane
      Title: Effect of juxtamembrane tryptophans on the immersion depth of Synaptobrevin, an integral vesicle membrane protein.
    2. a role for n-Syb in a neuron-specific sort-and-degrade mechanism that protects neurons from degeneration.
      Title: The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration.
    3. Expression of syb can restore synaptic transmission to n-syb mutants as assayed both by electroretinogram and recordings of excitatory junctional currents at the neuromuscular junction.
      Title: Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability.
    4. Our study suggests a novel, cell type-specific function of n-Syb in synaptogenesis and it distinguishes between two synapse types: TNT resistant and TNT sensitive ones.
      Title: Distinct functions of neuronal synaptobrevin in developing and mature fly photoreceptors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables SNAP receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal synaptobrevin
    Names
    CG17248-PA
    CG17248-PE
    CG17248-PF
    CG17248-PG
    CG17248-PH
    CG17248-PI
    CG17248-PJ
    CG17248-PK
    N-synaptobrevin
    Neuronal-synaptobrevin
    Synaptobrevin-62A
    VAMP3
    nSyb-PA
    nSyb-PE
    nSyb-PF
    nSyb-PG
    nSyb-PH
    nSyb-PI
    nSyb-PJ
    nSyb-PK
    neural-synaptobrevin
    neuronal synaptogrevin
    synaptobrevin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1630348..1637752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259618.2 → NP_001246547.1  neuronal synaptobrevin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQJ1
      Conserved Domains (2) summary
      cd15870
      Location:49 → 111
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:48 → 129
      Synaptobrevin; Synaptobrevin

    2. NM_167905.4 → NP_728645.1  neuronal synaptobrevin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0C2
      Related
      FBpp0290116
      Conserved Domains (2) summary
      cd15870
      Location:49 → 111
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:48 → 129
      Synaptobrevin; Synaptobrevin

    3. NM_001274340.1 → NP_001261269.1  neuronal synaptobrevin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE71
      Conserved Domains (2) summary
      cd15870
      Location:40 → 102
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:39 → 120
      Synaptobrevin; Synaptobrevin

    4. NM_001274341.1 → NP_001261270.1  neuronal synaptobrevin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQJ1
      Conserved Domains (2) summary
      cd15870
      Location:40 → 102
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:39 → 120
      Synaptobrevin; Synaptobrevin

    5. NM_057710.6 → NP_477058.1  neuronal synaptobrevin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP85, M9PDW0, M9PE71, Q86BQ0, Q9W0C1, Q9W0C2
      Related
      FBpp0072697
      Conserved Domains (2) summary
      cd15870
      Location:40 → 102
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:39 → 120
      Synaptobrevin; Synaptobrevin

    6. NM_206234.4 → NP_995956.1  neuronal synaptobrevin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0C2
      Conserved Domains (2) summary
      cd15870
      Location:49 → 111
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:48 → 129
      Synaptobrevin; Synaptobrevin

    7. NM_167906.3 → NP_728646.2  neuronal synaptobrevin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728646.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQJ1
      Conserved Domains (2) summary
      cd15870
      Location:49 → 111
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:48 → 129
      Synaptobrevin; Synaptobrevin

    8. NM_167904.3 → NP_728644.1  neuronal synaptobrevin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP85, M9PDW0, M9PE71, Q86BQ0, Q9W0C1, Q9W0C2
      Related
      FBpp0290115
      Conserved Domains (2) summary
      cd15870
      Location:40 → 102
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:39 → 120
      Synaptobrevin; Synaptobrevin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0C1.1 Q9W0C1

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