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    Hayan hayan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hayanprovided by FlyBase
    Official Full Name
    hayanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030925
    Locus tag
    Dmel_CG6361
    See related
    AllianceGenome:FB:FBgn0030925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP31; CG6361; cSP31; Dmel\CG6361; SP31
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade; defense response to fungus; and positive regulation of melanization defense response. Predicted to be active in extracellular space. Is expressed in several structures, including anterior endoderm; dorsal ectoderm; dorsal epidermis primordium; embryonic/larval midgut primordium; and gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hayan in Genome Data Viewer
    Location:
    17B4-17B5; 1-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18479983..18483772, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18374016..18377805, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43842 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45714 Neighboring gene persephone Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Refinement of a technique for collecting and evaluating the osmolality of haemolymph from Drosophila larvae. Kurio M, et al. J Exp Biol, 2024 Apr 15. PMID 38634259
    2. Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila. Takeishi A, et al. Cell Rep, 2013 Mar 28. PMID 23523355
    3. Drosophila innate immunity: regional and functional specialization of prophenoloxidases. Dudzic JP, et al. BMC Biol, 2015 Oct 1. PMID 26437768, Free PMC Article
    4. The Drosophila clotting system and its messages for mammals. Theopold U, et al. Dev Comp Immunol, 2014 Jan. PMID 23545286
    5. A specific innate immune response silences the virulence of Pseudomonas aeruginosa in a latent infection model in the Drosophila melanogaster host. Chen J, et al. PLoS Pathog, 2024 Jun. PMID 38833496, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hayan
    Names
    CG6361-PA
    CG6361-PB
    CG6361-PD
    Hayan-PA
    Hayan-PB
    Hayan-PD
    NP_001097020.1
    NP_001259684.2
    NP_573296.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18479983..18483772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103550.2 → NP_001097020.1  hayan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVC7, A8JUP7, M9PJQ8, Q8SY50, Q9VWU2
      Conserved Domains (3) summary
      smart00680
      Location:32 → 80
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:384 → 627
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:385 → 630
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_133068.3 → NP_573296.2  hayan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573296.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUP7
      Related
      FBpp0074401
      Conserved Domains (3) summary
      smart00680
      Location:32 → 80
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:125 → 368
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:126 → 371
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001272755.2 → NP_001259684.2  hayan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259684.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVC7, A8JUP7, M9PJQ8, Q8SY50, Q9VWU2
      Conserved Domains (3) summary
      smart00680
      Location:32 → 80
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:384 → 627
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:385 → 630
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUP7.1 A8JUP7

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