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    Smg6 Smg6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smg6provided by FlyBase
    Official Full Name
    Smg6provided by FlyBase
    Primary source
    FLYBASE:FBgn0039260
    Locus tag
    Dmel_CG6369
    See related
    AllianceGenome:FB:FBgn0039260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6369; Dmel\CG6369; DmSmg6; dSMG6; SMG6
    Summary
    Enables RNA nuclease activity. Involved in neuromuscular synaptic transmission; regulation of gene expression; and synapse organization. Predicted to be located in cytosol. Predicted to be part of telomerase holoenzyme complex. Is expressed in organism. Orthologous to human SMG6 (SMG6 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smg6 in Genome Data Viewer
    Location:
    96B17-96B17; 3-86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25029429..25033465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20855151..20859187, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-4-galactosyltransferase 7 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene Hormone receptor-like in 96 Neighboring gene YTH N6-methyladenosine RNA binding protein Neighboring gene uncharacterized protein Neighboring gene Inositol polyphosphate-5-phosphatase type I Neighboring gene baiser

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. Huntzinger E, et al. RNA, 2008 Dec. PMID 18974281, Free PMC Article
    2. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. Glavan F, et al. EMBO J, 2006 Nov 1. PMID 17053788, Free PMC Article
    3. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Nelson JO, et al. Genetics, 2018 Aug. PMID 29903866, Free PMC Article
    4. Circadian regulation of the Drosophila astrocyte transcriptome. You S, et al. PLoS Genet, 2021 Sep. PMID 34543266, Free PMC Article
    5. The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. Long AA, et al. J Cell Sci, 2010 Oct 1. PMID 20826458, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMG6 is a conserved endonuclease that degrades mRNAs terminating translation prematurely in metazoa
      Title: SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Smg6
    Names
    CG6369-PA
    Smg6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25029429..25033465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143064.2 → NP_651321.1  Smg6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BS8, Q9VBZ6
      Related
      FBpp0084171
      Conserved Domains (4) summary
      cd09885
      Location:767 → 941
      PIN_Smg6; PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      pfam10373
      Location:310 → 638
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:190 → 298
      EST1; Telomerase activating protein Est1
      cl21455
      Location:616 → 769
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BS8 Q86BS8
    Q8MZI0 Q8MZI0
    Q9VBZ6 Q9VBZ6

    Gene LinkOut

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