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    Gmppb GDP-mannose pyrophosphorylase B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmppbprovided by FlyBase
    Official Full Name
    GDP-mannose pyrophosphorylase Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037279
    Locus tag
    Dmel_CG1129
    See related
    AllianceGenome:FB:FBgn0037279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1129; Dmel\CG1129
    Summary
    Predicted to enable mannose-1-phosphate guanylyltransferase (GTP) activity. Involved in larval lymph gland hemopoiesis. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including amnioserosa; embryonic proventriculus intermediate layer; embryonic/larval midgut primordium; foregut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B14. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gmppb in Genome Data Viewer
    Location:
    82D6-82D6; 3-47.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4811444..4816025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (637166..641747)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing protein 39 Neighboring gene circadian trip Neighboring gene Hus1-like Neighboring gene uncharacterized protein Neighboring gene Bardet-Biedl syndrome 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664
    2. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    3. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. Mondal BC, et al. Elife, 2014 Sep 8. PMID 25201876, Free PMC Article
    4. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
    5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-1-phosphate guanylyltransferase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-1-phosphate guanylyltransferase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-1-phosphate guanylyltransferase (GTP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GDP-mannose pyrophosphorylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GDP-mannose pyrophosphorylase B
    Names
    CG1129-PA
    CG1129-PB
    CG1129-PD
    CG1129-PE
    Gmppb-PA
    Gmppb-PB
    Gmppb-PD
    Gmppb-PE
    NP_001189177.2
    NP_001287164.1
    NP_649498.1
    NP_730877.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4811444..4816025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300235.1 → NP_001287164.1  GDP-mannose pyrophosphorylase B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287164.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JZB4
      UniProtKB/TrEMBL
      E2QCZ9
      Conserved Domains (3) summary
      cd06425
      Location:12 → 242
      M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
      COG1208
      Location:12 → 361
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:264 → 343
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    2. NM_141241.4 → NP_649498.1  GDP-mannose pyrophosphorylase B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JZB4
      UniProtKB/TrEMBL
      E2QCZ9
      Related
      FBpp0078511
      Conserved Domains (3) summary
      cd06425
      Location:12 → 242
      M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
      COG1208
      Location:12 → 361
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:264 → 343
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    3. NM_169021.4 → NP_730877.1  GDP-mannose pyrophosphorylase B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JZB4
      UniProtKB/TrEMBL
      E2QCZ9
      Related
      FBpp0078510
      Conserved Domains (3) summary
      cd06425
      Location:12 → 242
      M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
      COG1208
      Location:12 → 361
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:264 → 343
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    4. NM_001202248.2 → NP_001189177.2  GDP-mannose pyrophosphorylase B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189177.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JZB4
      UniProtKB/TrEMBL
      E2QCZ9
      Conserved Domains (3) summary
      cd06425
      Location:12 → 242
      M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
      COG1208
      Location:12 → 361
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:264 → 343
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCZ9 E2QCZ9
    Q7JZB4.1 Q7JZB4

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