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    lgs legless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgsprovided by FlyBase
    Official Full Name
    leglessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039907
    Locus tag
    Dmel_CG2041
    See related
    AllianceGenome:FB:FBgn0039907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BCL9; Bcl9/9l; CG2041; Dm Lgs; Dmel\CG2041; Lgl; Lgs
    Summary
    Enables transcription coactivator activity. Involved in several processes, including instar larval or pupal development; positive regulation of transcription by RNA polymerase II; and regionalization. Located in nucleus. Part of beta-catenin-TCF complex. Is expressed in embryonic epidermis; germline cell; organism; primordial germ cell; and wing disc. Used to study chromosome 1q21.1 deletion syndrome. Orthologous to human BCL9L (BCL9 like) and BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lgs in Genome Data Viewer
    Location:
    102B8-102C1; 4-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (436957..443911, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (457583..464537, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43437 Neighboring gene long non-coding RNA:CR44024 Neighboring gene Calcium/calmodulin-dependent protein kinase I Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Brembeck FH, et al. Curr Opin Genet Dev, 2006 Feb. PMID 16377174
    2. beta-Catenin: a pivot between cell adhesion and Wnt signalling. Bienz M. Curr Biol, 2005 Jan 26. PMID 15668160
    3. Getting legless with a Pygopus. Greaves S. Nat Cell Biol, 2002 May. PMID 11988754
    4. Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2. Miller TC, et al. Structure, 2013 Dec 3. PMID 24183574, Free PMC Article
    5. The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3. Kessler R, et al. Mech Dev, 2009 Aug-Sep. PMID 19493659

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors used CRISPR/Cas9 genome engineering of Drosophila legless (lgs) and human BCL9 and B9L to show that the C-terminus downstream of their adaptor elements is crucial for Wnt responses.
      Title: Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.
    2. the PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3
      Title: The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.
    3. Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me).
      Title: Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.
    4. identifed conserved residues within Pygopus that are required for binding to Legless in votro
      Title: Pygopus residues required for its binding to Legless are critical for transcription and development.
    5. Pygo and Lgs function in targeting Armadillo/beta-catenin to the nucleus, thus ensuring its availability to TCF during Wnt signalling.
      Title: Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.
    6. Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.
      Title: Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sternite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    legless
    Names
    CG2041-PA
    lgs-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      436957..443911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143665.4 → NP_651922.1  legless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961D9, Q9V4D2
      Related
      FBpp0088180
      Conserved Domains (1) summary
      pfam11502
      Location:521 → 559
      BCL9; B-cell lymphoma 9 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961D9.1 Q961D9

    Gene LinkOut

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