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    casp caspar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    caspprovided by FlyBase
    Official Full Name
    casparprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034068
    Locus tag
    Dmel_CG8400
    See related
    AllianceGenome:FB:FBgn0034068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Casp; CASP; Caspar; CG8400; Dmel\CG8400; FAF1
    Summary
    Predicted to enable ubiquitin binding activity. Involved in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; negative regulation of peptidoglycan recognition protein signaling pathway; and negative regulation of proteolysis. Located in cytoplasm. Is expressed in organism. Orthologous to human FAF1 (Fas associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See casp in Genome Data Viewer
    Location:
    52D14-52D15; 2-76 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16024628..16028161, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11912133..11915666, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rrp42 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SP2353

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caspar SUMOylation regulates Drosophila lifespan. Kaduskar B, et al. MicroPubl Biol, 2020 Aug 2. PMID 32760885, Free PMC Article
    2. Age-dependent dynamics of neuronal VAPB(ALS) inclusions in the adult brain. Thulasidharan A, et al. Neurobiol Dis, 2024 Jun 15. PMID 38679111
    3. SUMO conjugation regulates immune signalling. Hegde S, et al. Fly (Austin), 2020 Mar-Dec. PMID 32777975, Free PMC Article
    4. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    5. Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease. Tendulkar S, et al. Hum Mol Genet, 2022 Aug 25. PMID 35377453, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspar
    Names
    CG8400-PA
    CG8400-PB
    CG8400-PC
    casp-PA
    casp-PB
    casp-PC
    casper

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16024628..16028161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206126.2 → NP_995848.1  caspar, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAP4, Q7JUP3
      Conserved Domains (4) summary
      cd01769
      Location:148 → 182
      UBL; Ubiquitin-like domain of UBL
      cd01771
      Location:616 → 695
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:392 → 530
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:12 → 44
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins

    2. NM_001299544.1 → NP_001286473.1  caspar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFH2, F0JAP4
      Conserved Domains (4) summary
      cd01769
      Location:143 → 177
      UBL; Ubiquitin-like domain of UBL
      cd01771
      Location:611 → 690
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:387 → 525
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:12 → 44
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins

    3. NM_137236.5 → NP_611080.1  caspar, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAP4, Q7JUP3
      Related
      FBpp0086397
      Conserved Domains (4) summary
      cd01769
      Location:148 → 182
      UBL; Ubiquitin-like domain of UBL
      cd01771
      Location:616 → 695
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:392 → 530
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:12 → 44
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFH2 A0A0B4LFH2
    Q7JUP3 Q7JUP3
    Q8T4G2 Q8T4G2

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