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    Poc1 Proteome of centrioles 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poc1provided by FlyBase
    Official Full Name
    Proteome of centrioles 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036354
    Locus tag
    Dmel_CG10191
    See related
    AllianceGenome:FB:FBgn0036354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10191; Dmel\CG10191; Pix; poc1; POC1
    Summary
    Involved in centrosome cycle. Predicted to be active in centriole and ciliary basal body. Is expressed in several structures, including CNS glial cell; antennal primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to several human genes including POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Poc1 in Genome Data Viewer
    Location:
    70A8-70A8; 3-40 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13388299..13390006, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13381399..13383106, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene senseless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pix proteins and the evolution of centrioles. Woodland HR, et al. PLoS One, 2008. PMID 19020665, Free PMC Article
    2. Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster. Jo KH, et al. Cells, 2019 Aug 5. PMID 31387336, Free PMC Article
    3. The proximal centriole-like structure maintains nucleus-centriole architecture in sperm. Buglak DB, et al. J Cell Sci, 2024 Sep 1. PMID 39166297, Free PMC Article
    4. Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations. Jaiswal A, et al. Open Biol, 2024 Sep. PMID 39255847, Free PMC Article
    5. A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Blachon S, et al. Genetics, 2009 May. PMID 19293139, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proteome of centrioles 1
    Names
    CG10191-PA
    CG10191-PB
    Poc1-PA
    Poc1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13388299..13390006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274870.1 → NP_001261799.1  proteome of centrioles 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCD6
      Conserved Domains (3) summary
      COG2319
      Location:14 → 388
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]

    2. NM_140383.2 → NP_648640.1  proteome of centrioles 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VU65
      Related
      FBpp0075597
      Conserved Domains (3) summary
      COG2319
      Location:14 → 298
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCD6 M9PCD6
    Q9VU65.1 Q9VU65

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