Bap60 Brahma associated protein 60kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bap60provided by FlyBase
Official Full Name: Brahma associated protein 60kDprovided by FlyBase
Primary source: FLYBASE:FBgn0025463
Locus tag: Dmel_CG4303
See related: AllianceGenome:FB:FBgn0025463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BAF60; bap60; BAP60; BAPp60; CG4303; dBAP60; Dmel\CG4303; i127; i133
Summary: Enables several functions, including DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and myosin binding activity. Contributes to transcription coactivator activity. Involved in negative regulation of neuroblast proliferation and regulation of gene expression. Located in euchromatin and nucleus. Part of brahma complex. Is expressed in several structures, including antennal anlage; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Used to study Coffin-Siris syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 11. Orthologous to several human genes including SMARCD1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11E1-11E1; 1-42 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13157445..13159508, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13051478..13053541, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

model of the SMARCD1 Drosophila ortholog Bap60, which has a role in the regulation of neurodevelopmental genes during a critical time window of juvenile adult brain development when neuronal circuits that are required for learning and memory are formed
Title: A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies.
BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.
Title: Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: brahma associated protein 60kD

Names: BRM-associated protein 60; Bap60-PA; CG4303-PA; brahma associated protein 60 kD; brahma associated protein 60 kDa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13157445..13159508 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078588.4 → NP_511143.2 brahma associated protein 60kD [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511143.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O76490, Q9VYG2

Related

FBpp0073572

Conserved Domains (1) summary

cd17674
Location:295 → 371

SWIB_BAF60A; SWIB domain found in BRG1-associated factor 60A (BAF60A) and similar proteins