rept reptin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: reptprovided by FlyBase
Official Full Name: reptinprovided by FlyBase
Primary source: FLYBASE:FBgn0040075
Locus tag: Dmel_CG9750
See related: AllianceGenome:FB:FBgn0040075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0142479.1; CG9750; Dmel\CG9750; drep; dRep; dReptin; dRUVBL2; l(3)06945; psg10; Q9V3K3_DROME; rep; REP; Rept; REPT; Reptin; Tip48; Tip48/Reptin
Summary: Enables transcription corepressor activity. Involved in several processes, including autophagic cell death; chromatin remodeling; and negative regulation of canonical Wnt signaling pathway. Located in nucleus. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and R2TP complex. Is expressed in several structures, including embryonic/larval midgut primordium; head epidermis primordium; mesoderm; sensory nervous system primordium; and visceral mesoderm derivative. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76A3-76A3; 3-45 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19255340..19257111)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19248440..19250211)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
The enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.
Title: Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
Rept and pontin have conserved their ability to bind to Myc during evolution
Title: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
Drosophila Reptin participates in epigenetic processes leading to a repressive chromatin state.
Title: Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in box C/D snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IC Inferred by Curator more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ino80 complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of R2TP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of R2TP complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: reptin

Names: CG9750-PA; CG9750-PB; CG9750-PC; dReptin; rept-PA; rept-PB; rept-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19255340..19257111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079432.3 → NP_524156.1 reptin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524156.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3K3

UniProtKB/TrEMBL

M9PFN1

Related

FBpp0074756

Conserved Domains (3) summary

cd00009
Location:267 → 358

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam06068
Location:17 → 408

TIP49; TIP49 C-terminus

cl21455
Location:69 → 113

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001300184.1 → NP_001287113.1 reptin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287113.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3K3

UniProtKB/TrEMBL

M9PFN1

Conserved Domains (3) summary

cd00009
Location:267 → 358

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam06068
Location:17 → 408

TIP49; TIP49 C-terminus

cl21455
Location:69 → 113

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001275111.1 → NP_001262040.1 reptin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262040.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3K3

UniProtKB/TrEMBL

M9PFN1

Conserved Domains (3) summary

cd00009
Location:267 → 358

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam06068
Location:17 → 408

TIP49; TIP49 C-terminus

cl21455
Location:69 → 113

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases