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    Smg5 Smg5 nonsense mediated mRNA decay factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smg5provided by FlyBase
    Official Full Name
    Smg5 nonsense mediated mRNA decay factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019890
    Locus tag
    Dmel_CG8954
    See related
    AllianceGenome:FB:FBgn0019890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-34Ea; BG:DS08220.2; br31; CG8954; Dmel\CG8954; dSMG5; l(2)34Eb; l(2)br31; l34Eb; smg5; SMG5; Smg5 nonsense RNA decay factor
    Summary
    Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of telomerase holoenzyme complex. Is expressed in several structures, including adult head; antennal anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human SMG5 (SMG5 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smg5 in Genome Data Viewer
    Location:
    34E2-34E2; 2-50 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13898828..13904661, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13898828..13904661, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centaurin gamma 1A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44848 Neighboring gene Angiotensin converting enzyme Neighboring gene Ance-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis. Hurst D, et al. Dev Biol, 2003 Feb 15. PMID 12591244
    2. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. Huntzinger E, et al. RNA, 2008 Dec. PMID 18974281, Free PMC Article
    3. Race: a Drosophila homologue of the angiotensin converting enzyme. Tatei K, et al. Mech Dev, 1995 Jun. PMID 7547464
    4. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. Glavan F, et al. EMBO J, 2006 Nov 1. PMID 17053788, Free PMC Article
    5. Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Zuniga G, et al. Alzheimers Dement, 2023 Feb. PMID 35416419, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results provide evidence that Smg5 is essential for nonsense-mediated messenger RNA activity.
      Title: Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Smg5 nonsense mediated mRNA decay factor
    Names
    CG8954-PA
    CG8954-PB
    CG8954-PC
    Smg5-PA
    Smg5-PB
    Smg5-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13898828..13904661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165069.2 → NP_723851.1  Smg5 nonsense mediated mRNA decay factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V414
      Related
      FBpp0080139
      Conserved Domains (3) summary
      cd09884
      Location:1012 → 1173
      PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
      pfam10373
      Location:240 → 478
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:99 → 222
      EST1; Telomerase activating protein Est1

    2. NM_001298985.1 → NP_001285914.1  Smg5 nonsense mediated mRNA decay factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V414
      Conserved Domains (3) summary
      cd09884
      Location:1012 → 1173
      PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
      pfam10373
      Location:240 → 478
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:99 → 222
      EST1; Telomerase activating protein Est1

    3. NM_135841.5 → NP_609685.1  Smg5 nonsense mediated mRNA decay factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V414
      Related
      FBpp0080138
      Conserved Domains (3) summary
      cd09884
      Location:1012 → 1173
      PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
      pfam10373
      Location:240 → 478
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:99 → 222
      EST1; Telomerase activating protein Est1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T080 Q8T080
    Q95TL1 Q95TL1
    Q9V414 Q9V414

    Gene LinkOut

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