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    Alg1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42146, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg1provided by FlyBase
    Official Full Name
    ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038552
    Locus tag
    Dmel_CG18012
    See related
    AllianceGenome:FB:FBgn0038552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18012; dAlg1; Dmel\CG18012
    Summary
    Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg1 in Genome Data Viewer
    Location:
    90C6-90C6; 3-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17809401..17811134, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13635123..13636848, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Oddjob Neighboring gene tincar Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning. Sung HH, et al. Nat Commun, 2024 Aug 27. PMID 39191750, Free PMC Article
    2. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953
    3. A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Fu Y, et al. Hum Mol Genet, 2017 Feb 15. PMID 28164240, Free PMC Article
    4. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    5. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
    Names
    Alg1-PA
    B-1,4-mannosyltransferase
    CG18012-PA
    NP_650662.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17809401..17811134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142405.3 → NP_650662.1  ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEE9
      Related
      FBpp0082947
      Conserved Domains (2) summary
      cd03816
      Location:6 → 442
      GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...
      PLN02275
      Location:7 → 402
      PLN02275; transferase, transferring glycosyl groups
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEE9 Q9VEE9

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