U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hll heimdall [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34822, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hllprovided by FlyBase
    Official Full Name
    heimdallprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286723
    Locus tag
    Dmel_CG4500
    See related
    AllianceGenome:FB:FBgn0286723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2a9; anon-EST:CL2a9; BG:DS05899.1; bgm-l; CG4500; dbb; Dmel\CG4500; I
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Involved in several processes, including neuron cellular homeostasis; positive regulation of circadian sleep/wake cycle, sleep; and triglyceride homeostasis. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval fat body; mesoderm; mesoderm anlage; ventral furrow; and yolk. Used to study adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hll in Genome Data Viewer
    Location:
    34F1-34F1; 2-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14027001..14029368)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14027001..14029368)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45352 Neighboring gene long non-coding RNA:CR31840 Neighboring gene long non-coding RNA:CR45284 Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor alpha5 Neighboring gene Nimrod C4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Sivachenko A, et al. Dis Model Mech, 2016 Apr. PMID 26893370, Free PMC Article
    2. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
    3. The acyl-CoA Synthetase, pudgy, Promotes Sleep and Is Required for the Homeostatic Response to Sleep Deprivation. Thimgan MS, et al. Front Endocrinol (Lausanne), 2018. PMID 30186232, Free PMC Article
    4. Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Gordon HB, et al. Dis Model Mech, 2018 Jun 15. PMID 29739804, Free PMC Article
    5. Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Zhang X, et al. Sci Total Environ, 2023 Aug 25. PMID 37196938

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    heimdall
    Names
    CG4500-PA
    bubblegum-like
    double bubble
    doublebubble
    hll-PA
    NP_609696.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14027001..14029368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135852.4 → NP_609696.1  heimdall [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWR5, Q9V3U0
      Related
      FBpp0080168
      Conserved Domains (1) summary
      cl17068
      Location:62 → 680
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3U0.1 Q9V3U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous