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    Alh Alhambra [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alhprovided by FlyBase
    Official Full Name
    Alhambraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261238
    Locus tag
    Dmel_CG1070
    See related
    AllianceGenome:FB:FBgn0261238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AF10; anon-WO0118547.226; CG1070; dAF10; Dalf; Dmel\CG1070; l(3)84Be; l(3)g2; l(3)g5; l(3)j13A6; l(3)j8c8; l(3)j8C8; l(3)r13; l(3j8C8; stk
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including haltere development; larval development; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; brain; embryonic/larval midgut primordium; head epidermis primordium; and larval neurons. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) and MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alh in Genome Data Viewer
    Location:
    84B6-84C3; 3-48 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7094596..7124185, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2920318..2949907, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 84B Neighboring gene long non-coding RNA:CR43685 Neighboring gene enhancer of yellow 2b Neighboring gene long non-coding RNA:CR45906 Neighboring gene Muscle LIM protein at 84B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila. Perrin L, et al. Mol Genet Genomics, 2004 Sep. PMID 15258852
    2. The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth. Bahri SM, et al. Mech Dev, 2001 Feb. PMID 11165485
    3. The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females. Narbey R, et al. Sci Rep, 2024 Apr 25. PMID 38664546, Free PMC Article
    4. The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation. Linder B, et al. EMBO Rep, 2001 Mar. PMID 11266362, Free PMC Article
    5. Homology-dependent silencing by an exogenous sequence in the Drosophila germline. Pöyhönen M, et al. G3 (Bethesda), 2012 Mar. PMID 22413086, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified a dominant mutation affecting the Alhambra (Alh) gene, the fly homologue of the human AF10 gene; show that the full-length ALH protein has no activity on Polycomb group-responsive elements (PREs)
      Title: The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.
    2. an independent lethal complementation group encoding a muscle protein (Mlp84B) is located within an Alh intron
      Title: Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in haltere development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alhambra
    Names
    Alh-PA
    Alh-PB
    Alh-PD
    Alh-PF
    Alh-PH
    Alh-PI
    Alh-PJ
    Alh-PK
    Alh-PL
    Alh-PM
    Alh-PN
    Alh-PO
    Alh-PP
    CG1070-PA
    CG1070-PB
    CG1070-PD
    CG1070-PF
    CG1070-PH
    CG1070-PI
    CG1070-PJ
    CG1070-PK
    CG1070-PL
    CG1070-PM
    CG1070-PN
    CG1070-PO
    CG1070-PP
    sticking

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7094596..7124185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275401.1 → NP_001262330.1  alhambra, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF76, Q962D2

    2. NM_001275402.1 → NP_001262331.1  alhambra, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFQ4

    3. NM_169170.3 → NP_731131.2  alhambra, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INT1, Q962D2

    4. NM_001170066.2 → NP_001163537.1  alhambra, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ75, Q962D2

    5. NM_001104227.3 → NP_001097697.2  alhambra, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097697.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQU6

    6. NM_001170065.2 → NP_001163536.1  alhambra, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ76

    7. NM_079526.3 → NP_524250.3  alhambra, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524250.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU77, Q9BMZ9, Q9NHX4, Q9VI63
      Related
      FBpp0081129
      Conserved Domains (2) summary
      cd15574
      Location:60 → 107
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15672
      Location:118 → 233
      ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

    8. NM_001275403.1 → NP_001262332.1  alhambra, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGP1, Q7YU77
      Conserved Domains (2) summary
      cd15574
      Location:60 → 107
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15672
      Location:118 → 233
      ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

    9. NM_001275399.1 → NP_001262328.1  alhambra, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGB4, Q7YU77
      Conserved Domains (2) summary
      cd15574
      Location:60 → 107
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15672
      Location:118 → 233
      ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

    10. NM_169171.2 → NP_731132.1  alhambra, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSZ0, Q962D1
      Related
      FBpp0081130
      Conserved Domains (2) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15672
      Location:65 → 180
      ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

    11. NM_001275400.1 → NP_001262329.1  alhambra, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFD2, Q962D1
      Conserved Domains (2) summary
      cd15574
      Location:7 → 54
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15672
      Location:65 → 180
      ePHD_AF10_like; Extended PHD finger found in protein AF-10 and AF-17

    12. NM_169172.3 → NP_731133.1  alhambra, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R1, Q9BMZ8, Q9VI61
      Related
      FBpp0081131

    13. NM_001104228.3 → NP_001097698.1  alhambra, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQU7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF76 A0A0B4KF76
    A0A0B4KFD2 A0A0B4KFD2
    A0A0B4KFQ4 A0A0B4KFQ4
    A0A0B4KGB4 A0A0B4KGB4
    A0A0B4KGP1 A0A0B4KGP1
    A8JQU6 A8JQU6
    A8JQU7 A8JQU7
    E1JJ75 E1JJ75
    E1JJ76 E1JJ76
    Q7KSZ0 Q7KSZ0
    Q7YU77 Q7YU77
    Q8INT1 Q8INT1
    Q8SZW9 Q8SZW9
    Q962D1 Q962D1
    Q962D2 Q962D2
    Q9BMZ8 Q9BMZ8
    Q9VI61 Q9VI61
    Q9VI63 Q9VI63

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