Cka Connector of kinase to AP-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ckaprovided by FlyBase
Official Full Name: Connector of kinase to AP-1provided by FlyBase
Primary source: FLYBASE:FBgn0044323
Locus tag: Dmel_CG7392
See related: AllianceGenome:FB:FBgn0044323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5836; anon-WO0172774.174; anon-WO0172774.175; anon-WO0172774.177; anon-WO0172774.179; CG7392; cka; CKA; Dcka; Dmel\CG7392; l(2)05836; l(2)s1883
Summary: Enables protein kinase binding activity. Involved in several processes, including morphogenesis of an epithelium; positive regulation of neuroblast proliferation; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including adult head and imaginal disc. Orthologous to several human genes including STRN3 (striatin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 28D3-28D3; 2-29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8030721..8040826)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8030721..8040826)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mob4/Cka/Mts functions as an intrinsic molecular switch coordinating Hippo and InR/PI3K/Akt pathways and enabling neural stem cells reactivation.
Title: STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.
A novel role for Strip/Cka in JNK pathway regulation during spermatogenesis within the developing Drosophila testis.
Title: Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: connector of kinase to AP-1

Names: AP-1; CG7392-PA; CG7392-PB; CG7392-PC; CG7392-PD; CG7392-PE; CG7392-PF; CG7392-PG; Cka-PA; Cka-PB; Cka-PC; Cka-PD; Cka-PE; Cka-PF; Cka-PG; WD-40-family-member; connector of kinase to

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8030721..8040826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164779.3 → NP_723334.1 connector of kinase to AP-1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723334.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86M30, Q95NF2, Q9VLT9

Related

FBpp0079159

Conserved Domains (4) summary

COG2319
Location:408 → 729

WD40; WD40 repeat [General function prediction only]

cd00200
Location:410 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:420 → 466

7WD40; WD40 repeat [structural motif]
NM_164781.3 → NP_723336.1 connector of kinase to AP-1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723336.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86M30, Q95NF2, Q9VLT9

Related

FBpp0079160

Conserved Domains (4) summary

COG2319
Location:408 → 729

WD40; WD40 repeat [General function prediction only]

cd00200
Location:410 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:420 → 466

7WD40; WD40 repeat [structural motif]
NM_001259007.2 → NP_001245936.1 connector of kinase to AP-1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245936.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DML3, Q86M30

Conserved Domains (4) summary

COG2319
Location:427 → 748

WD40; WD40 repeat [General function prediction only]

cd00200
Location:429 → 748

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:439 → 485

7WD40; WD40 repeat [structural motif]
NM_001273292.1 → NP_001260221.1 connector of kinase to AP-1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260221.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF42, Q86M30

Conserved Domains (4) summary

COG2319
Location:400 → 721

WD40; WD40 repeat [General function prediction only]

cd00200
Location:402 → 721

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:412 → 458

7WD40; WD40 repeat [structural motif]
NM_135333.3 → NP_609177.1 connector of kinase to AP-1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609177.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86M30, Q95NF2, Q9VLT9

Related

FBpp0079158

Conserved Domains (4) summary

COG2319
Location:408 → 729

WD40; WD40 repeat [General function prediction only]

cd00200
Location:410 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:420 → 466

7WD40; WD40 repeat [structural motif]
NM_001259008.2 → NP_001245937.1 connector of kinase to AP-1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245937.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NEC0, Q86M30

Conserved Domains (4) summary

COG2319
Location:425 → 746

WD40; WD40 repeat [General function prediction only]

cd00200
Location:427 → 746

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:437 → 483

7WD40; WD40 repeat [structural motif]
NM_164780.3 → NP_723335.1 connector of kinase to AP-1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723335.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86M30, Q95NF2, Q9VLT9

Related

FBpp0079161

Conserved Domains (4) summary

COG2319
Location:408 → 729

WD40; WD40 repeat [General function prediction only]

cd00200
Location:410 → 729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:98 → 228

Striatin; Striatin family

sd00039
Location:420 → 466

7WD40; WD40 repeat [structural motif]