Ote Otefin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Oteprovided by FlyBase
Official Full Name: Otefinprovided by FlyBase
Primary source: FLYBASE:FBgn0266420
Locus tag: Dmel_CG5581
See related: AllianceGenome:FB:FBgn0266420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5581; Dmel\CG5581; hal; ote; otefin
Summary: Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in several processes, including germ-line stem cell population maintenance; germ-line stem-cell niche homeostasis; and positive regulation of BMP signaling pathway. Located in nuclear envelope lumen; nuclear inner membrane; and nuclear periphery. Is expressed in several structures, including adult head; central brain primordium; ganglia; larval nervous system; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55C2-55C2; 2-85 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18275607..18277177, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14163112..14164682, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
loss of Bocksbeutel reduced Klarsicht localization to the nucleus and resulted in a disruption in nuclear separation. Loss of Otefin increased the transcription of Klarsicht and led to premature separation of nuclei and their positioning closer to the edge of the muscle.
Title: Drosophila emerins control LINC complex localization and transcription to regulate myonuclear position.
Ote is required autonomously for survival of male and female stem cell populations, as well as non-autonomously for maintenance of two somatic niches. Ote loss in ovary causes a decrease in cap cell number and altered signal transduction. Ote mutant males become prematurely sterile as they age.
Title: Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.
production of Bocks, but not dMAN1, rescued ote-/- sterility, demonstrating that Ote and Bocks are functional homologs
Title: Unique and shared functions of nuclear lamina LEM domain proteins in Drosophila.
We show that the primary defect in ote(-/-) GSCs is a block of differentiation, which ultimately leads to germ cell death.
Title: The Drosophila nuclear lamina protein otefin is required for germline stem cell survival.
Phosphorylation of Ote at T63 is critical for mitotic progression.
Title: Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression.
Data show that otefin is essential for germline stem cell (GSC) maintenance, is required for the Dpp/BMP signaling pathway to silence bam transcription, and that Ote physically interacts with Medea/Smad4 at the bam silencer element to regulate GSC fate.
Title: Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane reassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in oogenesis	HMP more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed