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    BTS1 farnesyltranstransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BTS1
    Official Full Name
    farnesyltranstransferase
    Primary source
    SGD:S000005990
    Locus tag
    YPL069C
    See related
    AllianceGenome:SGD:S000005990; FungiDB:YPL069C; VEuPathDB:YPL069C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables farnesyltranstransferase activity. Involved in terpenoid biosynthetic process. Is active in mitochondrion. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BTS1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (422885..423892, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene guanine nucleotide exchange factor MUK1 Neighboring gene uncharacterized protein Neighboring gene Htc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction. Chang CK, et al. Biochemistry, 2013 Apr 23. PMID 23534508
    2. Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase. Identification of essential amino acid residues for chain length determination of prenyltransferase reaction. Ohnuma S, et al. J Biol Chem, 1996 Aug 2. PMID 8702542
    3. An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase. Hemmi H, et al. Eur J Biochem, 2003 May. PMID 12752438
    4. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. Zhang Y, et al. J Am Chem Soc, 2009 Apr 15. PMID 19309137, Free PMC Article
    5. Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length. Noike M, et al. J Biosci Bioeng, 2009 Mar. PMID 19269584

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two amino acid residues in the first helix distal from the main dimer interface modulate the dimerization and activity of GGPP
      Title: Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables farnesyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables farnesyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables farnesyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in geranylgeranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in terpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in terpenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    farnesyltranstransferase
    NP_015256.1
    • Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      422885..423892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183883.1 → NP_015256.1  TPA: farnesyltranstransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3U6, Q12051
      UniProtKB/TrEMBL
      A6ZWI0, B3LL00, B5VT94, C7GTY8, C8ZIW1, G2WPB1, N1NVY0
      Conserved Domains (1) summary
      pfam00348
      Location:20 → 278
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12051.1

    Gene LinkOut

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