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    TUB1 alpha-tubulin TUB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854889, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TUB1
    Official Full Name
    alpha-tubulin TUB1
    Primary source
    SGD:S000004550
    Locus tag
    YML085C
    See related
    AllianceGenome:SGD:S000004550; FungiDB:YML085C; VEuPathDB:YML085C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in homologous chromosome segregation; mitotic sister chromatid segregation; and nuclear migration along microtubule. Located in nuclear periphery. Part of tubulin complex. Used to study amyotrophic lateral sclerosis type 22; lissencephaly (multiple); polymicrogyria; and thrombocytopenia. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 22; autosomal dominant isolated macrothrombocytopenia 2; keratoconus; lissencephaly (multiple); and visual epilepsy. Orthologous to several human genes including TUBA1A (tubulin alpha 1a); TUBA1B (tubulin alpha 1b); and TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TUB1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (97941..99400, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene cytochrome-b5 reductase Neighboring gene D-arabinono-1,4-lactone oxidase Neighboring gene uncharacterized protein Neighboring gene putative cystathionine gamma-synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubular dynamics of Saccharomyces cerevisiae temperature-sensitive secretory mutants: the sec 1 product and polymerization of microtubules. Briestanská J. Folia Biol (Praha), 1990. PMID 2279585
    2. Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin. Badin-Larçon AC, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15031428, Free PMC Article
    3. Single site alpha-tubulin mutation affects astral microtubules and nuclear positioning during anaphase in Saccharomyces cerevisiae: possible role for palmitoylation of alpha-tubulin. Caron JM, et al. Mol Biol Cell, 2001 Sep. PMID 11553707, Free PMC Article
    4. Tubulin and FtsZ form a distinct family of GTPases. Nogales E, et al. Nat Struct Biol, 1998 Jun. PMID 9628483
    5. Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy. Pearson CG, et al. Mol Biol Cell, 2006 Sep. PMID 16807354, Free PMC Article

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.
      Title: Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.
    2. An unexpected antagonism has been found between the tubulin-binding Stu2 domains (TOGs) and the lattice-binding basic region: lattice binding by the basic region is weak when at least two TOGs engage tubulins, strong when TOGs are empty.
      Title: Design principles of a microtubule polymerase.
    3. The polymerization blocked forms of alphabeta-tubulin give a lethal phenotype when expressed in cells.
      Title: Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.
    4. Disruption of microtubules by a temperature-sensitive allele of TUB1 stimulates P-body formation.
      Title: Microtubule disruption stimulates P-body formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration by microtubule mediated pushing forces IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tubulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tubulin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-tubulin TUB1
    NP_013625.1
    • Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      97941..99400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182444.1 → NP_013625.1  TPA: alpha-tubulin TUB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J8, P09733
      UniProtKB/TrEMBL
      A6ZLY0, B3LLH1, C7GW20, C8ZEB9, G2WJX0, N1NZ92
      Conserved Domains (1) summary
      cd02186
      Location:2 → 436
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09733.2

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